Department of Oncology, The First Affiliated Hospital, Nanchang University, Nanchang, 330006, Jiangxi, China.
Department of Pathology and Pathophysiology, School of Basic Medical and Biological Sciences, Soochow University, Suzhou, 215000, Jiangsu, China.
J Cancer Res Clin Oncol. 2023 Dec;149(20):18241-18252. doi: 10.1007/s00432-023-05488-2. Epub 2023 Nov 10.
The study aimed to explore the clinical and pathological characteristics, survival outcomes, and prognostic factors of colorectal hepatoid adenocarcinoma.
We performed two cases of colorectal hepatoid adenocarcinoma treated at the Oncology Department of the First Affiliated Hospital of Nanchang University. We also reviewed literature up to the present and performed a retrospective study of colorectal hepatoid adenocarcinoma.
Among the 39 patients included in this study, 28 had primary tumors in the colon, 9 in the rectum, and 2 in the rectosigmoid junction. The median age was 52 years (range 31-75 years); 28 patients (71.8%) were male. Out of the 32 patients for whom survival data were available, 24 patients succumbed to disease-related causes. The median overall survival of 32 patients was 8 months, with 1-year and 2-year overall survival rates of 31.0% and 16.0%, respectively. Univariate analysis revealed that depth of infiltration, presence of liver metastases, TNM stage, and the completeness of surgical resection were significantly associated with the overall survival period of colorectal hepatoid adenocarcinoma.
Colorectal hepatoid adenocarcinoma exhibits a high degree of aggressiveness and poor prognosis. The major strategy for early-stage HAC was radical surgery and chemoradiotherapy demonstrates limited efficacy for extending survival.
本研究旨在探讨结直肠肝样腺癌的临床病理特征、生存结局和预后因素。
我们对南昌大学第一附属医院肿瘤科收治的 2 例结直肠肝样腺癌患者进行了研究。我们还回顾了文献，并对结直肠肝样腺癌进行了回顾性研究。
在本研究纳入的 39 例患者中，28 例原发肿瘤位于结肠，9 例位于直肠，2 例位于直肠乙状结肠交界处。中位年龄为 52 岁（范围 31-75 岁）；28 例（71.8%）为男性。在可获得生存数据的 32 例患者中，有 24 例死于与疾病相关的原因。32 例患者的中位总生存期为 8 个月，1 年和 2 年总生存率分别为 31.0%和 16.0%。单因素分析显示，浸润深度、肝转移、TNM 分期和手术切除的完整性与结直肠肝样腺癌的总生存时间显著相关。
结直肠肝样腺癌具有高度侵袭性和不良预后。HAC 早期的主要策略是根治性手术，化疗和放疗在延长生存方面的效果有限。
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