Institute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Bonn, 53115 Bonn, Germany.
Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany; CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119529. doi: 10.1016/j.bbamcr.2023.119529. Epub 2023 Nov 9.
Mitochondria import 1000-1300 different precursor proteins from the cytosol. The main mitochondrial entry gate is formed by the translocase of the outer membrane (TOM complex). Molecular coupling and modification of TOM subunits control and modulate protein import in response to cellular signaling. The TOM complex functions as regulatory hub to integrate mitochondrial protein biogenesis and quality control into the cellular proteostasis network.
线粒体从细胞质中导入 1000-1300 种不同的前体蛋白。主要的线粒体进入门由外膜转位酶（TOM 复合物）形成。TOM 亚基的分子偶联和修饰控制并调节蛋白质导入，以响应细胞信号。TOM 复合物作为调节中心，将线粒体蛋白质生物发生和质量控制整合到细胞蛋白质稳态网络中。
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