Mizumoto S, Tamai S, Goshima J, Yajima H, Yoshii T, Fukui A, Masuhara K
J Reconstr Microsurg. 1986 Oct;3(1):1-11. doi: 10.1055/s-2007-1007031.
An experimental study of vascularized tibiofibula grafts in inbred rats was performed. Roentgenologic and histologic changes of the grafted bone in the first seven postoperative weeks were especially investigated. After preliminary experiments on the vascular anatomy of the lower limbs of rats, tibiofibular vascularized grafts with femoral artery and vein were utilized in Fischer strain F-344 rats. The rate of bony union in the vascularized graft group was superior to that in the nonvascularized control groups. Fluorochrome-labeling studies of the grafted bone at the mid-diaphysis showed active periosteal new bone formation, following the vascularized graft. In contrast, normal tibial bone growth at the mid-diaphysis was mainly endosteal. However, both vascularized graft and normal bone demonstrated evidence of a "drift phenomenon" in the direction of growth. Since the life cycle of the rat is very short, compared with other laboratory animals, this experimental model may be useful in investigating the postoperative course of vascularized bone grafts with a short follow-up period.
对近交系大鼠进行了带血管蒂胫腓骨移植的实验研究。特别研究了术后前七周移植骨的X线和组织学变化。在对大鼠下肢血管解剖进行初步实验后，在Fischer品系F - 344大鼠中使用带股动静脉的胫腓骨带血管蒂移植。带血管蒂移植组的骨愈合率优于非血管化对照组。对骨干中部移植骨的荧光标记研究表明，带血管蒂移植后骨膜有活跃的新骨形成。相比之下，骨干中部正常胫骨的生长主要是骨内膜性的。然而，带血管蒂移植骨和正常骨在生长方向上均表现出“漂移现象”。由于与其他实验动物相比，大鼠的生命周期非常短，该实验模型可能有助于在短随访期内研究带血管蒂骨移植的术后过程。
