Knasel A L, Collins-Barrow M D
J Natl Med Assoc. 1986 Nov;78(11):1037-40.
Leukocytosis, blood glucose, vomiting, diarrhea, and abdominal radiograph have been reported as early indicators of toxic serum iron levels. To test the applicability of this battery of five variables, the charts of 64 patients admitted for toxic iron ingestion were reviewed. When these variables were subjected to tests of sensitivity, specificity, and predictive negative and positive values in 42 patients meeting study criteria, they failed to reach statistical significance. Only vomiting was found to approach statistical significance and, therefore, may serve as an early indicator of toxicity. In addition, several epidemiological issues relevant to the study population are discussed.
白细胞增多、血糖、呕吐、腹泻和腹部X光片已被报告为血清铁中毒水平的早期指标。为了测试这五个变量组合的适用性，我们回顾了64例因摄入有毒铁而入院的患者病历。当对符合研究标准的42例患者的这些变量进行敏感性、特异性以及阴性和阳性预测值测试时，它们未达到统计学显著性。仅呕吐被发现接近统计学显著性，因此，可作为毒性的早期指标。此外，还讨论了与研究人群相关的几个流行病学问题。
