Qiu Chaohui, Li Xiaolong, Li Zhe, Yang Liu, Wang Weimin, Xu Fuxing, Ding Chuan-Fan
School of Material Science and Chemical Engineering, Ningbo University, Ningbo, China.
Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, Ningbo University, Ningbo, China.
Rapid Commun Mass Spectrom. 2023 Dec 30;37(24):e9648. doi: 10.1002/rcm.9648.
By applying radio frequency (RF) and direct current (DC) voltages to corresponding ring electrodes, ion funnel (IF) can efficiently focus and transmit ions. However, IF has an inherent mass discrimination problem that will greatly limit low mass-to-charge (m/z) ion focusing and transmission. To improve the transmission efficiency (TE) of the IF, this paper explores three new profile quadrupole ion funnels (QIF).
Computer simulations of the potential field distributions of QIFs and conventional IFs were performed to assess their focusing characteristics. To compare the TE, ion optics simulation programs SIMION and AXSIM were used to perform a series of simulations. Three QIF types (toroidal, cylindrical, and hyperbolic configurations) were used to improve ion TE, and their transmission and focus performance were also compared with conventional IF.
By simulating the trajectories of ions in the IF, the optimum electrical parameters for three new QIFs were obtained and compared with conventional IFs, with TE improvements recorded for m/z < 100 of 16%, 20%, and 13%.
The results indicate that studying these three new IF configurations has great research significance for improving sensitivity to low m/z ions in mass spectrometer instruments.
通过向相应的环形电极施加射频（RF）和直流（DC）电压，离子漏斗（IF）可以有效地聚焦和传输离子。然而，离子漏斗存在固有的质量歧视问题，这将极大地限制低质荷比（m/z）离子的聚焦和传输。为了提高离子漏斗的传输效率（TE），本文探索了三种新型的异形四极杆离子漏斗（QIF）。
对异形四极杆离子漏斗和传统离子漏斗的势场分布进行计算机模拟，以评估它们的聚焦特性。为了比较传输效率，使用离子光学模拟程序SIMION和AXSIM进行了一系列模拟。使用三种类型的异形四极杆离子漏斗（环形、圆柱形和双曲线形配置）来提高离子传输效率，并将它们的传输和聚焦性能与传统离子漏斗进行比较。
通过模拟离子在离子漏斗中的轨迹，获得了三种新型异形四极杆离子漏斗的最佳电学参数，并与传统离子漏斗进行了比较，对于质荷比小于100的离子，传输效率提高了16%、20%和13%。
结果表明，研究这三种新型离子漏斗配置对于提高质谱仪仪器中低质荷比离子的灵敏度具有重要的研究意义。
