Disease Elimination Program, Burnet Institute, Melbourne, VIC, Australia.
Department of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia.
Epidemiol Infect. 2023 Nov 13;151:e192. doi: 10.1017/S0950268823001784.
People who inject drugs are at risk of acute bacterial and fungal injecting-related infections. There is evidence that incidence of hospitalizations for injecting-related infections are increasing in several countries, but little is known at an individual level. We aimed to examine injecting-related infections in a linked longitudinal cohort of people who inject drugs in Melbourne, Australia. A retrospective descriptive analysis was conducted to estimate the prevalence and incidence of injecting-related infections using administrative emergency department and hospital separation datasets linked to the SuperMIX cohort, from 2008 to 2018. Over the study period, 33% (95%CI: 31-36%) of participants presented to emergency department with any injecting-related infections and 27% (95%CI: 25-30%) were admitted to hospital. Of 1,044 emergency department presentations and 740 hospital separations, skin and soft tissue infections were most common, 88% and 76%, respectively. From 2008 to 2018, there was a substantial increase in emergency department presentations and hospital separations with any injecting-related infections, 48 to 135 per 1,000 person-years, and 18 to 102 per 1,000 person-years, respectively. The results emphasize that injecting-related infections are increasing, and that new models of care are needed to help prevent and facilitate early detection of superficial infection to avoid potentially life-threatening severe infections.
注射毒品的人有感染急性细菌性和真菌性注射相关感染的风险。有证据表明，在几个国家，与注射相关的感染住院率正在上升，但在个人层面上知之甚少。我们旨在检查澳大利亚墨尔本一个与注射相关的纵向队列中注射毒品者的注射相关感染。对 2008 年至 2018 年与 SuperMIX 队列相关联的行政急诊部和医院分离数据集进行了回顾性描述性分析，以估计与注射相关的感染的患病率和发病率。在研究期间，33%（95%CI：31-36%）的参与者因任何与注射相关的感染到急诊部就诊，27%（95%CI：25-30%）住院。在 1044 次急诊就诊和 740 次住院分离中，皮肤和软组织感染最为常见，分别占 88%和 76%。从 2008 年到 2018 年，与任何与注射相关的感染相关的急诊就诊和住院分离的数量大幅增加，分别为每 1000 人年 48 至 135 例和每 1000 人年 18 至 102 例。结果强调了与注射相关的感染正在增加，需要新的护理模式来帮助预防和早期发现浅表感染，以避免潜在的威胁生命的严重感染。
