Izumi Kenji, Yortchan Witsanu, Aizawa Yuka, Kobayashi Ryota, Hoshikawa Emi, Ling Yiwei, Suzuki Ayako
Division of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Japan.
Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand.
Jpn Dent Sci Rev. 2023 Dec;59:365-374. doi: 10.1016/j.jdsr.2023.10.002. Epub 2023 Oct 25.
Many conditions, including cancer, trauma, and congenital anomalies, can damage the oral mucosa. Multiple cultures of oral mucosal cells have been used for biocompatibility tests and oral biology studies. In recent decades, the clinical translation of tissue-engineered products has progressed significantly in developing tangible therapies and inspiring advancements in medical science. However, the reconstruction of an intraoral mucosa defect remains a significant challenge. Despite the drawbacks of donor-site morbidity and limited tissue supply, the use of autologous oral mucosa remains the gold standard for oral mucosa reconstruction and repair. Tissue engineering offers a promising solution for repairing and reconstructing oral mucosa tissues. Cell- and scaffold-based tissue engineering approaches have been employed to treat various soft tissue defects, suggesting the potential clinical use of tissue-engineered oral mucosa (TEOMs). In this review, we first cover the recent trends in the reconstruction and regeneration of extra-/intra-oral wounds using TEOMs. Next, we describe the current status and challenges of TEOMs. Finally, future strategic approaches and potential technologies to support the advancement of TEOMs for clinical use are discussed.
包括癌症、创伤和先天性畸形在内的多种病症都可能损害口腔黏膜。口腔黏膜细胞的多种培养物已用于生物相容性测试和口腔生物学研究。近几十年来，组织工程产品的临床转化在开发切实可行的治疗方法和推动医学科学进步方面取得了显著进展。然而，口腔黏膜缺损的重建仍然是一项重大挑战。尽管存在供区发病和组织供应有限的缺点，但自体口腔黏膜的使用仍然是口腔黏膜重建和修复的金标准。组织工程为修复和重建口腔黏膜组织提供了一个有前景的解决方案。基于细胞和支架的组织工程方法已被用于治疗各种软组织缺损，这表明组织工程化口腔黏膜（TEOMs）具有潜在的临床应用价值。在这篇综述中，我们首先介绍使用TEOMs进行口腔外/口腔内伤口重建和再生的最新趋势。接下来，我们描述TEOMs的现状和挑战。最后，讨论支持TEOMs临床应用发展的未来战略方法和潜在技术。
