Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 637459, Singapore, Singapore.
Angew Chem Int Ed Engl. 2024 Feb 5;63(6):e202314468. doi: 10.1002/anie.202314468. Epub 2023 Nov 23.
Molecularly generated light, referred to here as "molecular light", mainly includes bioluminescence, chemiluminescence, and Cerenkov luminescence. Molecular light possesses unique dual features of being both a molecule and a source of light. Its molecular nature enables it to be delivered as molecules to regions deep within the body, overcoming the limitations of natural sunlight and physically generated light sources like lasers and LEDs. Simultaneously, its light properties make it valuable for applications such as imaging, photodynamic therapy, photo-oxidative therapy, and photobiomodulation. In this review article, we provide an updated overview of the diverse applications of molecular light and discuss the strengths and weaknesses of molecular light across various domains. Lastly, we present forward-looking perspectives on the potential of molecular light in the realms of molecular imaging, photobiological mechanisms, therapeutic applications, and photobiomodulation. While some of these perspectives may be considered bold and contentious, our intent is to inspire further innovations in the field of molecular light applications.
分子产生的光，在这里被称为“分子光”，主要包括生物发光、化学发光和切伦科夫辐射发光。分子光具有独特的双重特性，既是分子又是光源。它的分子性质使其能够作为分子被递送到体内深处的区域，克服了自然光和激光、LED 等物理产生的光源的局限性。同时，它的光特性使其在成像、光动力疗法、光氧化疗法和光生物调节等应用中具有价值。在这篇综述文章中，我们提供了分子光的多样化应用的最新概述，并讨论了分子光在各个领域的优缺点。最后，我们对分子光在分子成像、光生物机制、治疗应用和光生物调节领域的潜力提出了前瞻性的观点。虽然其中一些观点可能被认为是大胆和有争议的，但我们的意图是激发分子光应用领域的进一步创新。
