Sungu Nuran, Kıran Merve M
Department of Pathology, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
Department of Pathology, Ankara City Hospital, Ankara, Turkey.
Pol J Pathol. 2023;74(3):161-170. doi: 10.5114/pjp.2023.132221.
It has been reported that mismatch repair deficient (d-MMR) tumors show sensitivity to immune checkpoint inhibitors. We aimed to evaluate the correlation of d-MMR and PD-1/PD-L1 expression in invasive urothelial carcinoma of the bladder. Tissue microarray (TMA) tissues were stained PD-1/PD-L1 and MMR proteins. The expression ratio of these markers has been compared with histopathologic parameters. d-MMR tumors were more superficial muscle invasive (p = 0.012). When the d-MMR, and PD-1/PD-L1 expression ratios were examined, a significant correlation was obtained between the d-MMR and PD-L1 expression ratio of > 5% in both the tumor and immune cells (p = 0.02 and p = 0.004, respectively). The expression ratio was higher in the patients without MMR loss. PD-1 and PD-L1expression in those with MSH6 loss was one or none. When PD1/PDL1 expression was compared with histopathological parameters, a significant relationship was observed between tumor grade and depth of muscle invasion. PD-L1 expression was not observed in the superficial muscle invasive tumors. This study was shown the status of d-MMR and PD-1/PD-L1 in invasive urothelial cancers and their correlation with prognostic markers. PD-1/PD-L1 expression may contribute to the progression and poor prognosis of bladder cancer. However, further studies are required to research the clinical utility.
据报道，错配修复缺陷（d-MMR）肿瘤对免疫检查点抑制剂敏感。我们旨在评估膀胱浸润性尿路上皮癌中d-MMR与PD-1/PD-L1表达的相关性。组织微阵列（TMA）组织进行了PD-1/PD-L1和MMR蛋白染色。这些标志物的表达率与组织病理学参数进行了比较。d-MMR肿瘤更易侵犯浅肌层（p = 0.012）。当检查d-MMR和PD-1/PD-L1表达率时，在肿瘤细胞和免疫细胞中d-MMR与PD-L1表达率>5%之间存在显著相关性（分别为p = 0.02和p = 0.004）。在无MMR缺失的患者中表达率更高。MSH6缺失患者中PD-1和PD-L1表达为1例或无表达。当将PD1/PDL1表达与组织病理学参数进行比较时，观察到肿瘤分级与肌层浸润深度之间存在显著关系。在浅肌层浸润性肿瘤中未观察到PD-L1表达。本研究显示了浸润性尿路上皮癌中d-MMR和PD-1/PD-L1的状态及其与预后标志物的相关性。PD-1/PD-L1表达可能促进膀胱癌的进展和预后不良。然而，需要进一步研究以探讨其临床应用价值。
