Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA; Department of Medicine (Hepatology), Albert Einstein College of Medicine, Bronx, NY, 10461, USA; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, 10461, USA; Montefiore-Einstein Comprehensive Cancer Research Center, Albert Einstein College of Medicine, Bronx, NY, 10461, USA; Cancer Dormancy Tumor Microenvironment Institute, Albert Einstein College of Medicine, Bronx, NY, 10461, USA; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, USA.
Curr Opin Cell Biol. 2023 Dec;85:102276. doi: 10.1016/j.ceb.2023.102276. Epub 2023 Nov 11.
Cell migration is a complex and intricate network of physical, chemical, and molecular events that ultimately leads to cell motility. This phenomenon is involved in both physiological and pathological processes such as proper immune and inflammatory responses. Dysregulation of cell migration machinery in immune cells can have a tremendous impact on the trajectory of inflammation, infection, and resolution. The small vertebrate, the zebrafish, has a remarkable capacity for genetic and pharmacological manipulation aligned to transparency that enables modulation and visualization of cell migration in vivo noninvasively. Such characteristics revolutionized the field of leukocyte biology, particularly neutrophils. In this review, we will focus on leukocyte migration and highlight findings made in the zebrafish that demonstrate how this small vertebrate system is a unique model to perform in vivo imaging and study mechanisms that regulate the dynamic behavior of immune cells in their native environment under homeostasis or upon challenge.
细胞迁移是一个复杂而精细的物理、化学和分子事件网络，最终导致细胞运动。这种现象涉及生理和病理过程，如适当的免疫和炎症反应。免疫细胞中细胞迁移机制的失调会对炎症、感染和消退的轨迹产生巨大影响。小型脊椎动物斑马鱼具有出色的遗传和药理学操作能力，并具有透明性，能够在体内非侵入性地调节和可视化细胞迁移。这些特性彻底改变了白细胞生物学领域，尤其是中性粒细胞。在这篇综述中，我们将重点介绍白细胞迁移，并强调在斑马鱼中发现的结果，这些结果表明这个小型脊椎动物系统是一个独特的模型，可以在体内进行成像，并研究在稳态或受到挑战时调节免疫细胞在其天然环境中动态行为的机制。
