Nishioka T, Sekiguchi T, Machida M, Kusano M, Kogure M, Matsuzaki T, Katoh R, Horikoshi T, Fukagawa H, Tajima H
Nihon Heikatsukin Gakkai Zasshi. 1986 Apr;22(2):103-12. doi: 10.1540/jsmr1965.22.103.
Manometric study was performed to investigate the effects of cisapride, a new non-antidopaminergic gastrointestinal prokinetic compound, on interdigestive lower esophageal sphincter pressure (LESP) and gastroduodenal motility using infused catheter technique. The subjects consisted of 9 healthy volunteers and 29 patients with progressive systemic sclerosis (19), reflux esophagitis (8) and others (2). 4 mg of cisapride was given by bolus injection, continuous infusion or oral administration. The following results were obtained: Intravenous and oral cisapride increased LESP compared with basal pressure. Especially, bolus injection of cisapride caused a significant elevation of LESP during 30 minutes after administration. After administration of cisapride, gastroduodenal motility was accelerated gradually, then inducing IMC-like contractions. By bolus injection, IMC-like contractions were induced in healthy subjects more frequently than in patients group. On the other hand, motility index of stomach and duodenum showed persistent increase in patients group compared with healthy subjects. Cisapride-induced IMC-like contractions initiated from LES and upper part of stomach and mediated to duodenum, though aborad migration was not confirmed in the present study.
采用灌注导管技术进行测压研究，以探讨新型非抗多巴胺能胃肠促动力化合物西沙必利对消化间期下食管括约肌压力（LESP）及胃十二指肠动力的影响。研究对象包括9名健康志愿者和29例进行性系统性硬化症患者（19例）、反流性食管炎患者（8例）及其他患者（2例）。通过静脉推注、持续输注或口服给予4mg西沙必利。结果如下：与基础压力相比，静脉注射和口服西沙必利均可增加LESP。尤其是，静脉推注西沙必利后30分钟内可使LESP显著升高。给予西沙必利后，胃十二指肠动力逐渐加快，继而诱发类似移行性复合运动（IMC）的收缩。静脉推注时，健康受试者比患者组更频繁地诱发类似IMC的收缩。另一方面，与健康受试者相比，患者组胃和十二指肠的动力指数持续升高。西沙必利诱发的类似IMC的收缩起始于LES和胃上部，并向十二指肠传导，尽管在本研究中未证实其向远端迁移。
