Rossi Antonio, Montefusco Laura, Reseghetti Elia, Pastore Ida Fabrizia, Rossi Giada, Usuelli Vera, Loretelli Cristian, Boci Denisa, Ben Nasr Moufida, D'Addio Francesca, Bucciarelli Loredana, Argenti Sabrina, Morpurgo Paola, Lunati Maria Elena, Fiorina Paolo
Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.
Dept. Biomedical and Clinical Sciences "L. Sacco", University of Milan, Milan, Italy.
Diabetes Res Clin Pract. 2023 Dec;206:111011. doi: 10.1016/j.diabres.2023.111011. Epub 2023 Nov 11.
The use of advanced hybrid closed loop systems is spreading due to the beneficial effects on glycometabolic control obtained in patients with type 1 diabetes. However, hypoglycemic episodes can be sometimes a matter of concern. We aim to compare the hypoglycemic risk of an advanced hybrid closed loop system and a predictive low glucose suspend sensor augmented pump.
In this retrospective three months observational study, we included 30 patients using Medtronic Minimed™ 780G advanced hybrid closed loop system and 30 patients using a Medtronic Minimed™ predictive low glucose suspend sensor augmented pump.
The advanced hybrid closed loop system reduced the time spent above 180 mg/dL threshold and increased the time in range as compared to the predictive low glucose suspend. No severe hypoglycemia occurred in both groups and no differences were observed in the percentage of time spent below 70 mg/dl and 54 mg/dl glucose threshold. Nevertheless, more hypoglycemic episodes were recorded during daytime, but not in nighttime, with the use of the advanced hybrid closed loop system.
Our results confirmed the general improvement of glycemic outcomes obtained with the advanced hybrid closed loop system; however more hypoglycemic episodes during daytime were evident.
由于对1型糖尿病患者的糖代谢控制有有益影响，先进的混合闭环系统的使用正在推广。然而，低血糖事件有时可能令人担忧。我们旨在比较先进的混合闭环系统和预测性低血糖暂停传感器增强泵的低血糖风险。
在这项为期三个月的回顾性观察研究中，我们纳入了30名使用美敦力MiniMed™ 780G先进混合闭环系统的患者和30名使用美敦力MiniMed™ 预测性低血糖暂停传感器增强泵的患者。
与预测性低血糖暂停相比，先进的混合闭环系统减少了血糖高于180mg/dL阈值的时间，并增加了血糖在目标范围内的时间。两组均未发生严重低血糖，血糖低于70mg/dl和54mg/dl阈值的时间百分比也未观察到差异。然而，使用先进的混合闭环系统时，白天记录到更多的低血糖事件，但夜间没有。
我们的结果证实了先进的混合闭环系统在血糖控制方面的总体改善；然而，白天明显有更多的低血糖事件。
