Future Tech Laboratory, Corporate Research & Development, UBE Corporation, 8-1 Goi-Minamikaigan, Chiba 290-0045, Japan.
Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Int J Mol Sci. 2023 Oct 30;24(21):15765. doi: 10.3390/ijms242115765.
(1) The global population is projected to reach a staggering 9.8 billion people by the year 2050, leading to major concerns about food security. The necessity to increase livestock production is inevitable. The black soldier fly (BSF) is known for its ability to consume a wide range of organic waste, and BSF larvae have already been used as a partial substitute for fishmeal. In contrast, the use of antibiotics in livestock feed for growth promotion and prophylaxis poses a severe threat to global health owing to antimicrobial resistance. Insect antimicrobial peptides (AMPs) have shown the potential to rapidly disrupt target bacterial membranes, making bacterial resistance to AMPs a less likely concern. (2) In this study, we explored various methods for stimulating AMP synthesis in BSF larvae and found that thermal injury effectively induced the production of various AMP types. Additionally, we investigated the activation of innate immune response pathways that lead to AMP production following thermal injury. (3) Interestingly, thermal injury treatment, although not involving bacteria, exhibited a similar response to that observed following Gram-positive bacterial infection in eliciting the expression of AMP genes. (4) Our findings offer support for the industrial use of BSF to enhance livestock production and promote environmental health.
(1) 预计到 2050 年，全球人口将达到令人震惊的 98 亿，这引发了人们对粮食安全的极大关注。增加畜牧业生产是必然的。黑水虻（BSF）以能够消耗广泛的有机废物而闻名，并且 BSF 幼虫已经被用作鱼粉的部分替代品。相比之下，抗生素在促进生长和预防疾病的牲畜饲料中的使用对全球健康构成了严重威胁，因为抗生素耐药性。昆虫抗菌肽（AMPs）已显示出快速破坏目标细菌膜的潜力，从而使细菌对抗 AMP 的耐药性不太可能成为问题。(2) 在这项研究中，我们探索了刺激 BSF 幼虫 AMP 合成的各种方法，发现热损伤能有效地诱导各种 AMP 类型的产生。此外，我们研究了导致热损伤后 AMP 产生的先天免疫反应途径的激活。(3) 有趣的是，热损伤处理虽然不涉及细菌，但在引发 AMP 基因表达方面，与革兰氏阳性菌感染后的反应相似。(4) 我们的研究结果支持将 BSF 用于提高畜牧业生产和促进环境健康的工业用途。
