Czajkowska Sylwia, Rupa-Matysek Joanna, Nijakowski Kacper, Gil Lidia, Surdacka Anna, Kulczyk Tomasz
Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
J Clin Med. 2023 Nov 2;12(21):6901. doi: 10.3390/jcm12216901.
Hemophilia is associated with an increased risk of developing osteoporosis and osteopenia. The aim of the study was to interpret the usefulness of fractal analysis of the trabecular bone of the mandible (FD) and selected radiomorphic indices (the antegonial index (AI) and Klemetti index (KI)) to assess the risk of reduced bone mineral density (BMD) in patients with hemophilia A/B.
The study group consisted of 50 patients with type A/B hemophilia. The control group consisted of 25 males without congenital bleeding disorders. The patients had a panoramic radiograph taken with the same X-ray machine (Vistapano S, Durr Dental, Bietigheim-Bissingen, Germany). The AudaXCeph software (Audax d.o.o., Ljubljana, Slovenia) was used to evaluate the AI index, and the ImageJ, software with a specially prepared script, was used to evaluate the FD. The mandibular cortex was assessed distal to the mental foramen using the Klemetti index.
There were no statistically significant differences between the AI, KI and FD values between the study group and the control group.
This study indicated the lack of usefulness of AI, KI and fractal analysis in identifying patients with hemophilia at risk of reduced bone mass.
血友病与骨质疏松症和骨质减少症的发病风险增加有关。本研究的目的是解读下颌骨小梁骨的分形分析（FD）以及选定的放射形态学指标（下颌角前切迹指数（AI）和克莱梅蒂指数（KI））在评估甲型/乙型血友病患者骨矿物质密度（BMD）降低风险方面的作用。
研究组由50例甲型/乙型血友病患者组成。对照组由25名无先天性出血性疾病的男性组成。所有患者均使用同一台X射线机（Vistapano S，德国迪尔牙科公司，比蒂希海姆 - 比辛根）拍摄全景X线片。使用AudaXCeph软件（斯洛文尼亚卢布尔雅那的Audax d.o.o.公司）评估AI指数，使用带有专门编写脚本的ImageJ软件评估FD。使用克莱梅蒂指数评估颏孔远端的下颌骨皮质。
研究组与对照组之间的AI、KI和FD值无统计学显著差异。
本研究表明，AI、KI和分形分析在识别有骨质减少风险的血友病患者方面没有作用。
