Depatment of Nuclear Medicine, CHU Montpellier, 34295 Montpellier, France.
Physiology and Experimental Medicine of the Heart and Muscles (PhyMedExp), University of Montpellier, 34295 Montpellier, France.
Nutrients. 2023 Oct 25;15(21):4517. doi: 10.3390/nu15214517.
It is well documented that lean tissue mass (LTM) decreases with aging in patients with obesity, but there is no information available regarding muscle strength changes, a parameter that may be better associated with sarcopenic obesity (SO). The objectives of this study were to analyze the changes in LTM and fat mass (FM), muscle strength and muscle function with aging in women with obesity and to determine the prevalence of SO. LTM and FM were determined by DXA, muscle strength with the hand-grip test and muscle function with the 6 min walk test (6MWT) in 383 women with obesity. A redistribution of the LTM and FM occurred with age, characterized by a gain at the trunk to the detriment of the lower limbs, thus reducting in appendicular LTM indices. The physical performances evaluated by the muscle strength and muscle function decreased concomitantly, and the prevalence of low values for both these parameters was 22.8% and 13.4%, respectively, in the older patients. In summary, although a reduction in appendicular LTM and muscle performances occurred with age and resulted in an increase in the prevalence of SO, the number of women with obesity affected by SO remained low ( ≤ 15), even in those older than 60 years.
有大量文献记载，肥胖患者的去脂体重（LTM）会随着年龄的增长而减少，但目前尚无关于肌肉力量变化的信息，而肌肉力量可能与肌肉减少性肥胖（SO）的相关性更好。本研究的目的是分析肥胖女性随年龄增长时 LTM 和脂肪量（FM）、肌肉力量和肌肉功能的变化，并确定 SO 的患病率。通过 DXA 测定 LTM 和 FM，用握力测试测定肌肉力量，用 6 分钟步行测试（6MWT）测定肌肉功能，对 383 名肥胖女性进行了评估。随着年龄的增长，LTM 和 FM 发生了重新分布，表现为躯干的增加而下肢的减少，从而降低了四肢的 LTM 指数。肌肉力量和肌肉功能评估的身体表现也随之下降，这两个参数低值的患病率在老年患者中分别为 22.8%和 13.4%。综上所述，尽管随着年龄的增长，四肢 LTM 和肌肉功能会减少，导致 SO 的患病率增加，但受 SO 影响的肥胖女性人数仍然较少（≤15%），即使是 60 岁以上的患者也是如此。
