肌肉减少症和身体成分与骨质疏松症的关系。

Relationship of sarcopenia and body composition with osteoporosis.

作者信息

He H, Liu Y, Tian Q, Papasian C J, Hu T, Deng H-W

机构信息

Center of Genomics and Bioinformatics, Tulane University, New Orleans, LA, 70118, USA.

Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St., Suite 2001, New Orleans, LA, 70112, USA.

出版信息

Osteoporos Int. 2016 Feb;27(2):473-82. doi: 10.1007/s00198-015-3241-8. Epub 2015 Aug 5.

DOI:10.1007/s00198-015-3241-8

PMID:26243357

Abstract

UNLABELLED

The purpose of the study is to investigate the relationship between sarcopenia and body composition and osteoporosis in cohorts of three different races with a total of 17,891 subjects. Lean mass and grip strength were positively associated with bone mineral densities (BMDs). Subjects with sarcopenia were two times more likely to have osteoporosis compared with normal subjects.

INTRODUCTION

The relationship between sarcopenia and osteoporosis is not totally clear. First, the present study assessed this relationship by using two different definitions for sarcopenia. Second, we examined the associations of body composition (including muscle mass as a major and important component) and muscle strength on regional and whole-body BMDs.

METHODS

In total, 17,891 subjects of African American, Caucasian, and Chinese ethnicities were analyzed. Sarcopenia was defined by relative appendicular skeletal muscle mass (RASM) cut points and also by the definition of the European Working Group on Sarcopenia in Older People (low RASM plus low muscle function). Multiple regression analyses were conducted to examine the association of fat mass, lean mass (including muscle mass), and grip strength with regional and whole-body BMDs. Multivariate logistic regression analysis was performed to explore the association between sarcopenia and osteopenia/osteoporosis.

RESULTS

BMDs were positively associated with lean mass and negatively associated with fat mass, after controlling for potential confounders. Grip strength was significantly associated with higher BMDs. Each standard deviation (SD) increase in RASM resulted in a ~37 % reduction in risk of osteopenia/osteoporosis (odds ratio (OR) = 0.63; 95 % confidence interval (CI) = 0.59, 0.66). Subjects with sarcopenia defined by RASM were two times more likely to have osteopenia/osteoporosis compared with the normal subjects (OR = 2.04; 95 % CI = 1.61, 2.60). Similarly, subjects with sarcopenia (low muscle mass and low grip strength) were ~1.8 times more likely to have osteopenia/osteoporosis than normal subjects (OR = 1.87; 95 % CI = 1.09, 3.20).

CONCLUSIONS

High lean mass and muscle strength were positively associated with BMDs. Sarcopenia is associated with low BMD and osteoporosis.

摘要

未标注

本研究的目的是调查17891名来自三个不同种族队列中的肌肉减少症与身体成分及骨质疏松症之间的关系。去脂体重和握力与骨密度（BMD）呈正相关。与正常受试者相比，患有肌肉减少症的受试者患骨质疏松症的可能性高出两倍。

引言

肌肉减少症与骨质疏松症之间的关系尚不完全清楚。首先，本研究通过使用两种不同的肌肉减少症定义来评估这种关系。其次，我们研究了身体成分（包括作为主要和重要组成部分的肌肉质量）和肌肉力量与局部和全身骨密度之间的关联。

方法

总共分析了17891名非裔美国人、白种人和中国人受试者。肌肉减少症通过相对四肢骨骼肌质量（RASM）切点定义，并采用欧洲老年人肌肉减少症工作组的定义（低RASM加低肌肉功能）。进行多元回归分析以研究脂肪量、去脂体重（包括肌肉质量）和握力与局部和全身骨密度之间的关联。进行多变量逻辑回归分析以探讨肌肉减少症与骨质减少/骨质疏松症之间的关联。

结果

在控制潜在混杂因素后，骨密度与去脂体重呈正相关，与脂肪量呈负相关。握力与较高的骨密度显著相关。RASM每增加一个标准差（SD），骨质减少/骨质疏松症的风险降低约37%（比值比（OR）=0.63；95%置信区间（CI）=0.59，0.66）。与正常受试者相比，由RASM定义的患有肌肉减少症的受试者患骨质减少/骨质疏松症的可能性高出两倍（OR=2.04；95%CI=1.61，2.60）。同样，患有肌肉减少症（低肌肉质量和低握力）的受试者患骨质减少/骨质疏松症的可能性比正常受试者高出约1.8倍（OR=1.87；95%CI=1.09，3.20）。