Verma Ajay K, Nandakumar Bharadwaj, Acedillo Kit, Yu Ying, Marshall Ethan, Schneck David, Fiecas Mark, Wang Jing, MacKinnon Colum D, Howell Michael J, Vitek Jerrold L, Johnson Luke A
Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
bioRxiv. 2023 Nov 1:2023.10.28.564524. doi: 10.1101/2023.10.28.564524.
Increasing evidence associates slow-wave sleep (SWS) dysfunction with neurodegeneration. Using a within-subject design in the nonhuman primate model of Parkinson's disease (PD), we found that reduced SWS quantity in mild parkinsonism was accompanied by elevated beta and reduced delta power during SWS in the motor cortex. Our findings support excessive beta oscillations as a mechanism for SWS dysfunction and will inform development of neuromodulation therapies for enhancing SWS in PD.
越来越多的证据表明慢波睡眠（SWS）功能障碍与神经退行性变有关。在帕金森病（PD）的非人灵长类动物模型中采用受试者内设计，我们发现轻度帕金森病中慢波睡眠量减少伴随着运动皮层慢波睡眠期间β功率升高和δ功率降低。我们的研究结果支持过度的β振荡是慢波睡眠功能障碍的一种机制，并将为开发用于增强帕金森病患者慢波睡眠的神经调节疗法提供依据。
