Unkun Tuba, Geçmen Çetin, Çap Murat, İzci Servet, Erdoğan Emrah, Önal Çağatay, Acar Rezzan Deniz, Bakal Ruken Bengi, Kaymaz Cihangir, Özdemir Nihal
Department of Cardiology, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Türkiye.
Department of Cardiology, Dr. Gazi Yaşargil Training and Research Hospital, Diyarbakır, Türkiye.
Anatol J Cardiol. 2023 Nov 14;28(2):94-101. doi: 10.14744/AnatolJCardiol.2023.3064.
Early systolic lengthening is a echocardiographic strain parameter previously used to determine the lesion severity in patients with stable coronary artery disease. In the present study, we aimed to evaluate the relationship between early systolic lengthening and anatomic SYNTAX score in troponin (-) and (+) groups among patients with non-ST-elevation acute coronary syndrome (ACS).
A total of 95 patients diagnosed with non-ST-elevation ACS were included in the prospective, non-randomized, single-center study. The patients were categorized into 2 groups as troponin (+) and troponin (-). The patients were evaluated in terms of echocardiographic, clinical, and angiographic parameters.
The baseline characteristics, including age (58 ± 13 vs. 60 ± 10 respectively, P =.340), a history of hypertension (67.1% vs. 64%, respectively, P =.479), diabetes (28.6% vs. 32%, respectively, P =.467), global longitudinal strain (-14.37 ± 5.11 vs. -16.42 ± 3.93, respectively, P =.095), left ventricular ejection fraction (58.71 ± 8.73 vs. 57.20 ± 8.70, respectively, P =.263), and E/e' (8.44 ± 2.13 vs. 8.33 ± 1.99, respectively, P =.785), were similar between troponin (+) and troponin (-) groups. Left ventricle end-systolic diameter (3.2 ± 0.78; 3.50 ± 0.74 vs. 3.2 ± 0.78, respectively, P =.031), left ventricle end-systolic volume (55.57 ± 32.17 vs. 38.28 ± 13.63, respectively, P =.013), left ventricle end-diastolic volume (115.31 ± 49.54 vs. 91.23 ± 20.57, respectively, P =.042), the rate of early systolic lengthening (65.7% vs. 28%, respectively, P =.001), the duration of early systolic lengthening (24.02 ± 31 ms vs. 15.56 ± 30.19 ms, respectively, P =.009), and the SYNTAX score (16 ± 11 vs. 10 ± 10, respectively, P =.023) were higher in the troponin (+) group. Furthermore, a significant correlation was found between early systolic lengthening and SYNTAX score (r = 0.43, P <.001).
The rate and duration of early systolic lengthening were higher in patients in the troponin (+) group. Early systolic lengthening is related to SYNTAX score in patients with non-ST-elevation ACS.
收缩早期延长是一种超声心动图应变参数，以前用于确定稳定型冠状动脉疾病患者的病变严重程度。在本研究中，我们旨在评估非ST段抬高型急性冠状动脉综合征（ACS）患者中肌钙蛋白（-）和（+）组的收缩早期延长与解剖学SYNTAX评分之间的关系。
共有95例诊断为非ST段抬高型ACS的患者纳入了这项前瞻性、非随机、单中心研究。患者被分为肌钙蛋白（+）组和肌钙蛋白（-）组。对患者进行了超声心动图、临床和血管造影参数评估。
肌钙蛋白（+）组和肌钙蛋白（-）组之间的基线特征相似，包括年龄（分别为58±13岁和60±10岁，P = 0.340）、高血压病史（分别为67.1%和64%，P = 0.479）、糖尿病（分别为28.6%和32%，P = 0.467）、整体纵向应变（分别为-14.37±5.11和-16.42±3.93，P = 0.095）、左心室射血分数（分别为58.71±8.73和57.20±8.70，P = 0.263）以及E/e'（分别为8.44±2.13和8.33±1.99，P = 0.785）。肌钙蛋白（+）组的左心室收缩末期直径（分别为3.2±0.78；3.50±0.74对3.2±0.78，P = 0.031）、左心室收缩末期容积（分别为55.57±32.17和38.28±13.63，P = 0.013）、左心室舒张末期容积（分别为115.31±49.54和91.23±20.57，P = 0.042）、收缩早期延长率（分别为65.7%和28%，P = 0.001）、收缩早期延长持续时间（分别为24.02±31毫秒和15.56±30.19毫秒，P = 0.009）以及SYNTAX评分（分别为16±11和1
