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抗病毒治疗的现状(作者译)

[Present state of antiviral therapy (author's transl)].

作者信息

ter Meulen V

出版信息

Monatsschr Kinderheilkd (1902). 1979 Jun;127(6):367-71.

PMID:379620
Abstract

Application of antiviral drugs in viral infections is still limited to few diseases. Most of the preparations available induce strong side effects since these substances not only interfere with virus replication but also with cell metabolism. Therefore, only in severe diseases such as herpes simplex encephalitis or complications of varizella zoster infection such a treatment is advisable. From a clinical point of view an antiviral drug would be desirable which selectively inhibitis virus growths without affecting the host. This can already be achieved with interferon. However, at the present time the quantities of interferon needed for such treatment are not available.

摘要

抗病毒药物在病毒感染中的应用仍局限于少数疾病。现有的大多数制剂都会引发强烈的副作用,因为这些物质不仅会干扰病毒复制,还会影响细胞代谢。因此,只有在诸如单纯疱疹性脑炎或水痘带状疱疹感染并发症等严重疾病中,这种治疗才是可取的。从临床角度来看,理想的抗病毒药物应该是能够选择性抑制病毒生长而不影响宿主。干扰素已经能够做到这一点。然而,目前用于这种治疗所需的干扰素数量尚无法获得。

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