Program in Liberal Medical Education, Brown University, Providence, Rhode Island, USA.
Division of Ophthalmology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Graefes Arch Clin Exp Ophthalmol. 2024 Apr;262(4):1181-1193. doi: 10.1007/s00417-023-06286-9. Epub 2023 Nov 14.
Retained foreign objects (RFOs) can place patients undergoing cataract surgery at risk for significant vision-threatening complications. In this systematic review, we examine the characteristics, clinical outcomes, and management of RFOs originating from surgical instruments or the surgical field after routine cataract surgery.
Using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we searched five databases in June 2023. The inclusion criteria were peer-reviewed, full-text, English-language articles describing RFOs after routine cataract surgery. Studies that described non-routine cataract surgeries, patients with a history of ocular trauma, or organic RFOs were excluded. Two investigators independently extracted data and appraised the methodological quality of each study using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE).
Twenty-eight studies were included in our qualitative synthesis describing metal, fiber, and plastic RFOs. Typically, the RFOs were detected during surgery or slit-lamp examination. Presentations of patients with metal or fiber RFOs varied, with some being asymptomatic. Patients with plastic RFOs were usually symptomatic, often with decreased visual acuity and/or anterior chamber inflammation. Metal RFOs may have originated from metal fatigue from prolonged instrument usage and contact between surgical instruments, fiber RFOs from surgical wipes and gauzes, and plastic RFOs from instrument wrapping and intraocular lens defects. Factors such as location, biocompatibility, and secondary intraocular inflammation influenced the decision to surgically remove RFOs. Following surgical removal, the signs and symptoms resolved in most patients with RFOs. The studies' GRADE ratings indicated limitations in risk of bias and imprecision.
The presentation and management of RFOs varied depending on the type of material. To prevent RFOs, clinicians should carefully inspect surgical instruments and packs and use fiber-free wipes, towels, and gauzes. Future studies should investigate the efficacy and cost-effectiveness of different RFO prevention strategies.
残留异物(RFO)可使接受白内障手术的患者面临严重威胁视力的并发症风险。在本系统评价中,我们检查了常规白内障手术后源自手术器械或手术区域的 RFO 的特征、临床结果和处理方法。
使用系统评价和荟萃分析的首选报告项目(PRISMA)指南,我们于 2023 年 6 月在五个数据库中进行了搜索。纳入标准为描述常规白内障手术后 RFO 的同行评审、全文、英语文章。排除描述非常规白内障手术、有眼部创伤史或有机 RFO 的研究。两名调查员独立提取数据,并使用推荐评估、制定与评价(GRADE)分级评估每个研究的方法学质量。
我们的定性综合描述了 28 项研究中金属、纤维和塑料 RFO。通常,RFO 是在手术或裂隙灯检查中发现的。金属或纤维 RFO 患者的表现各不相同,有些无症状。塑料 RFO 患者通常有症状,常伴有视力下降和/或前房炎症。金属 RFO 可能源自手术器械长时间使用和器械接触引起的金属疲劳、纤维 RFO 源自手术擦拭布和纱布、塑料 RFO 源自器械包装和人工晶状体缺陷。位置、生物相容性和继发性眼内炎症等因素影响了是否进行手术切除 RFO 的决定。在进行手术切除后,大多数 RFO 患者的体征和症状得到缓解。研究的 GRADE 评分表明存在偏倚风险和不精确性的局限性。
RFO 的表现和处理方法因材料类型而异。为了预防 RFO,临床医生应仔细检查手术器械和器械包,并使用无纤维擦拭布、毛巾和纱布。未来的研究应调查不同 RFO 预防策略的疗效和成本效益。