小胶质细胞在代谢的中枢控制中的作用
Microglia in Central Control of Metabolism.
机构信息
Institute of Human Nutrition, Columbia University Irving Medical Center, New York, New York, United States.
Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, New York, United States.
出版信息
Physiology (Bethesda). 2024 Jan 1;39(1):0. doi: 10.1152/physiol.00021.2023. Epub 2023 Nov 14.
Abstract
Beyond their role as brain immune cells, microglia act as metabolic sensors in response to changes in nutrient availability, thus playing a role in energy homeostasis. This review highlights the evidence and challenges of studying the role of microglia in metabolism regulation.
摘要
除了作为大脑免疫细胞的作用外，小胶质细胞还可以作为代谢传感器，对营养物质可用性的变化做出反应，从而在能量平衡中发挥作用。本文重点介绍了研究小胶质细胞在代谢调节中的作用的证据和挑战。
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