Hulunbuir Clinical Medical College, Inner Mongolia MinZu University, Hulunbuir, Inner Mongolia, China.
Department of Neurology, Hulunbuir People's Hospital, Hulunbuir, Inner Mongolia, China.
Neurocase. 2023 Feb-Apr;29(1):1-5. doi: 10.1080/13554794.2023.2280276. Epub 2023 Dec 16.
To study a case of a middle-aged male with a non-tumor-associated Epstein-Barr virus (EBV) infection associated with Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE), to explore the role of EBV in the pathogenesis of anti-NMDARE. The patient was diagnosed with "Anti-NMDARE, EBV infection" by using Cerebrospinal fluid (CSF) autoimmune encephalitis profile, and Metagenomics Next-Generation Sequencing (mNGS) pathogenic microbial assays, we discuss the relationship between EBV and NMDARE by reviewed literature. EBV infection may trigger and enhance anti-NMDARE, and the higher the titer of NMDAR antibody, the more severe the clinical presentation.
研究一例与非肿瘤相关的 EBV（Epstein-Barr virus）感染相关的抗 N-甲基-D-天冬氨酸受体脑炎（NMDARE）的中年男性病例，以探讨 EBV 在抗 NMDARE 发病机制中的作用。该患者通过使用脑脊液（CSF）自身免疫性脑炎谱和宏基因组下一代测序（mNGS）致病微生物检测，被诊断为“抗 NMDARE，EBV 感染”，我们通过文献复习讨论了 EBV 与 NMDARE 之间的关系。EBV 感染可能引发和增强抗 NMDARE，且 NMDAR 抗体滴度越高，临床症状越严重。
