Université Grenoble Alpes, CNRS, CEA, Inserm UA13 BGE, Grenoble, France.
Phytother Res. 2024 Feb;38(2):636-645. doi: 10.1002/ptr.8063. Epub 2023 Nov 14.
Hyperforin is a phloroglucinol derivative isolated from the medicinal plant Hypericum perforatum (St John's wort, SJW). This lipophilic biomolecule displays antibacterial, pro-apoptotic, antiproliferative, and anti-inflammatory activities. In addition, in vitro and in vivo data showed that hyperforin is a promising molecule with potential applications in neurology and psychiatry. For instance, hyperforin possesses antidepressant properties, impairs the uptake of neurotransmitters, and stimulates the brain derived neurotrophic factor (BDNF)/TrkB neurotrophic signaling pathway, the adult hippocampal neurogenesis, and the brain homeostasis of zinc. In fact, hyperforin is a multi-target biomolecule with a complex neuropharmacological profile. However, one prominent pharmacological feature of hyperforin is its ability to influence the homeostasis of cations such as Ca , Na , Zn , and H . So far, the pathophysiological relevance of these actions is currently unknown. The main objective of the present work is to provide an overview of the cellular neurobiology of hyperforin, with a special focus on its effects on neuronal membranes and the movement of cations.
金丝桃素是从药用植物贯叶连翘（圣约翰草，SJW）中分离得到的苯丙素衍生物。这种亲脂性生物分子具有抗菌、促凋亡、抗增殖和抗炎作用。此外，体外和体内数据表明，金丝桃素是一种很有前途的分子，具有在神经病学和精神病学方面的潜在应用。例如，金丝桃素具有抗抑郁作用，可损害神经递质的摄取，并刺激脑源性神经营养因子（BDNF）/TrkB 神经营养信号通路、成年海马神经发生和锌的大脑内稳态。事实上，金丝桃素是一种具有复杂神经药理学特征的多靶点生物分子。然而，金丝桃素的一个突出的药理学特征是它能够影响 Ca、Na、Zn 和 H 等阳离子的内稳态。到目前为止，这些作用的病理生理学相关性尚不清楚。本研究的主要目的是概述金丝桃素的细胞神经生物学，特别关注其对神经元膜和阳离子运动的影响。
