Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mol Imaging Biol. 2024 Feb;26(1):17-28. doi: 10.1007/s11307-023-01868-9. Epub 2023 Nov 14.
Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating efficacy and/or toxicities in such experiments, ensuring compliance with ethical standards for animal research, and, perhaps most importantly, providing reasonable initial estimates of normal-organ doses in humans, required for clinical translation of new radiopharmaceuticals. This MIB Guide provides a basic protocol for obtaining preclinical dosimetry estimates with organ-level dosimetry software.
临床前剂量学对于指导动物放射性药物生物分布、成像和治疗实验的设计，评估此类实验的疗效和/或毒性，确保符合动物研究的伦理标准，以及最重要的是，为新放射性药物的临床转化提供合理的人体正常器官剂量的初步估计，都是至关重要的。本 MIB 指南提供了使用器官水平剂量学软件获得临床前剂量学估算值的基本方案。
