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评估成人脊柱畸形手术后脊柱骨盆并发症的成本。

Estimating the Cost of Spinopelvic Complications After Adult Spinal Deformity Surgery.

作者信息

Zuckerman Scott L, Cher Daniel, Capobianco Robyn, Sciubba Daniel, Polly David W

机构信息

Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

SI-BONE, Inc, Santa Clara, CA, USA.

出版信息

Clinicoecon Outcomes Res. 2023 Nov 9;15:765-772. doi: 10.2147/CEOR.S437202. eCollection 2023.

Abstract

OBJECTIVE

Reoperations for spinopelvic failure after adult spinal deformity (ASD) surgery are common. We sought to determine the added costs of ASD surgery attributable to reoperations for spinopelvic construct failures.

METHODS

We constructed a Markov process model to calculate the expected discounted 5-year costs of spinopelvic construct failures after ASD surgery. The Nationwide Inpatient Sample (NIS) was queried to estimate the number of ASD surgeries. Model inputs were based on literature review and expert opinion. ASD surgery was defined as thoracolumbar fusion of 4 or more levels with pelvic fixation. The following pelvic fixation failures were included: 1) rod fracture or pseudarthrosis from L4-S1, 2) iliac screw failure or set plug dislodgment, 3) iliac screw prominence, and 4) sacroiliac (SI) joint pain. The number of patients undergoing ASD surgery annually in the US was determined using a commercial claims database.

RESULTS

The net present value 5-year cost per patient for spinopelvic complications was $35,265, equal to 29% of index surgery costs. Given an estimated 27,580 cases annually in the US, the additional cost to address spinopelvic complications reach nearly $1 billion over 5-years. A sensitivity analysis showed that these costs were most sensitive to the rate of rod fracture/pseudarthrosis, iliac screw prominence, and reoperation.

CONCLUSION

A conservative estimate of the cost of spinopelvic failures after ASD surgery is substantial, nearly $1 billion over 5-years. We propose a method of capturing spinopelvic fixation failures for use in future clinical studies and cost analyses.

摘要

目的

成人脊柱畸形(ASD)手术后因脊柱骨盆功能衰竭进行再次手术很常见。我们试图确定因脊柱骨盆内固定失败而进行再次手术所导致的ASD手术额外费用。

方法

我们构建了一个马尔可夫过程模型,以计算ASD手术后脊柱骨盆内固定失败的预期5年贴现成本。查询全国住院患者样本(NIS)以估计ASD手术的数量。模型输入基于文献综述和专家意见。ASD手术定义为4个或更多节段的胸腰椎融合并进行骨盆固定。包括以下骨盆固定失败情况:1)L4-S1节段的棒材骨折或假关节形成;2)髂骨螺钉失败或固定塞移位;3)髂骨螺钉突出;4)骶髂(SI)关节疼痛。使用商业索赔数据库确定美国每年接受ASD手术的患者数量。

结果

脊柱骨盆并发症每位患者的5年成本净现值为35,265美元,相当于初次手术成本的29%。鉴于美国每年估计有27,580例病例,解决脊柱骨盆并发症的额外成本在5年内接近10亿美元。敏感性分析表明,这些成本对棒材骨折/假关节形成率、髂骨螺钉突出和再次手术率最为敏感。

结论

对ASD手术后脊柱骨盆功能衰竭成本的保守估计相当可观,5年内接近10亿美元。我们提出了一种记录脊柱骨盆固定失败情况的方法,以供未来临床研究和成本分析使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae56/10642569/98efda173d27/CEOR-15-765-g0001.jpg

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