Tadros Michael M, Boshra Marian S, Scott Michael, Fleming Glenda, Magee Fidelma, Hamed Mohammad I, Abuelhana Ahmed, Courtenay Aaron, Salem Heba F, Burnett Kathryn
School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, UK.
Clinical Pharmacy Department, Faculty of Pharmacy, Misr University for Science and Technology (MUST University), P.O. Box 12566, Giza, Egypt.
JAC Antimicrob Resist. 2023 Nov 13;5(6):dlad117. doi: 10.1093/jacamr/dlad117. eCollection 2023 Dec.
Increased antimicrobial resistance patterns lead to limited options for antimicrobial agents, affecting patient health and increasing hospital costs.
To investigate the antimicrobial prescribing patterns at two district hospitals in Northern Ireland before and during the COVID-19 pandemic.
A mixed prospective-retrospective study was designed to compare pre- and during pandemic antimicrobial prescribing data in both hospitals using a Global Point Prevalence Survey.
Of the 591 patients surveyed in both hospitals, 43.8% were treated with 402 antimicrobials. A total of 82.8% of antimicrobial prescriptions were for empirical treatment. No significant difference existed in numbers of patients treated or antimicrobials used before and during the pandemic. There was a slight decrease of 3.3% in the compliance rate with hospital antimicrobial guidelines during the pandemic when compared with the pre-pandemic year of 2019, when it was 69.5%. Treatment based on patients' biomarker data also slightly decreased from 83.5% pre-pandemic (2019) to 81.5% during the pandemic (2021).
There was no overall significant impact of the pandemic on the antimicrobial prescribing patterns in either hospital when compared with the pre-pandemic findings. The antimicrobial stewardship programmes would appear to have played an important role in controlling antimicrobial consumption during the pandemic.
抗菌药物耐药模式增加导致抗菌药物选择受限，影响患者健康并增加医院成本。
调查新冠疫情之前及期间北爱尔兰两家地区医院的抗菌药物处方模式。
设计一项前瞻性与回顾性相结合的研究，采用全球现患率调查比较两家医院疫情前及疫情期间的抗菌药物处方数据。
在两家医院调查的591名患者中，43.8%的患者接受了402种抗菌药物治疗。总计82.8%的抗菌药物处方为经验性治疗。疫情之前和期间接受治疗的患者数量及使用的抗菌药物数量无显著差异。与2019年疫情前相比，疫情期间医院抗菌药物指南的依从率略有下降，2019年的依从率为69.5%，疫情期间下降了3.3%。基于患者生物标志物数据的治疗也略有下降，从疫情前（2019年）的83.5%降至疫情期间（2021年）的81.5%。
与疫情前的结果相比，疫情对两家医院的抗菌药物处方模式均未产生总体显著影响。抗菌药物管理计划在疫情期间控制抗菌药物消费方面似乎发挥了重要作用。
