Yokoyama H, Kida H, Asamato T, Abe T, Koshino Y, Hattori N
Nephron. 1986;44(4):361-4. doi: 10.1159/000184021.
Histological studies were performed on 3 patients with gout and proteinuria measured at 1.0 g a day or more. Light microscopy revealed diffuse thickening of the glomerular capillary walls accompanied by spike formation and bubble-like appearance as well as tophaceous granuloma in the interstitium, tubular atrophy and benign nephrosclerosis. Immunofluorescence technique showed fine granular deposits of IgG and C3 along the glomerular capillary walls together with the renal tubular epithelial antigen (RTE) in 1 patient. Subepithelial dense deposits were also observed by electron microscopy. These findings suggest that the association of membranous nephropathy should be considered in patients with gout having moderate to severe proteinuria and that RTE may be involved in the pathogenesis of subepithelial deposits in gouty membranous nephropathy.
对3例痛风且蛋白尿每日测量值达1.0克或更高的患者进行了组织学研究。光镜检查显示肾小球毛细血管壁弥漫性增厚，伴有钉突形成和泡状外观，以及间质内痛风石性肉芽肿、肾小管萎缩和良性肾硬化。免疫荧光技术显示，1例患者的肾小球毛细血管壁有IgG和C3的细颗粒状沉积物以及肾小管上皮抗原（RTE）。电镜检查还观察到上皮下致密沉积物。这些发现表明，对于有中度至重度蛋白尿的痛风患者，应考虑合并膜性肾病，并且RTE可能参与痛风性膜性肾病上皮下沉积物的发病机制。
