Dorfman L J, Gaynon M, Ceranski J, Louis A A, Howard J E
Neurology. 1987 Jan;37(1):123-8. doi: 10.1212/wnl.37.1.123.
Clinical neurophysiologists may be asked to participate in the evaluation of patients with injured eyes. We describe a method for eliciting evoked potentials of cerebral origin using electrical pulse stimuli delivered to the globe of the eye through a contact lens electrode mounted on the cornea. These visual electrical evoked potentials (VEEPs) are contrasted with conventional flash visual evoked potentials in normal subjects and in 19 eyes of 17 patients with severe ocular damage, mostly recent trauma. The findings suggest that the site of transcorneal electrical excitation is not the photoreceptors, but more likely one of the nerve cell layers of the retina. VEEP recordings offer a way to circumvent the opacification of the ocular media by blood, which may otherwise hamper the evaluation of retinal function in the injured eye. Preserved VEEP response does not necessarily predict the capacity to recover visual function. Absent VEEP response is an unfavorable prognostic sign, which may be considered in arriving at a decision about enucleation.
临床神经生理学家可能会被要求参与对眼部受伤患者的评估。我们描述了一种方法，即通过安装在角膜上的隐形眼镜电极向眼球传递电脉冲刺激，从而引出大脑起源的诱发电位。在正常受试者以及17例严重眼损伤（大多为近期外伤）患者的19只眼中，将这些视觉电诱发电位（VEEPs）与传统闪光视觉诱发电位进行了对比。研究结果表明，经角膜电刺激的部位不是光感受器，而更可能是视网膜的神经细胞层之一。VEEP记录提供了一种方法来规避血液导致的眼内介质混浊，否则这可能会妨碍对受伤眼睛视网膜功能的评估。保留的VEEP反应不一定能预测视觉功能恢复的能力。VEEP反应缺失是一个不良的预后迹象，在决定是否摘除眼球时可以考虑这一点。
