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[嗜铬细胞瘤的外科治疗]

[Surgical treatment of pheochromocytoma].

作者信息

Shikhmagomedov Sh Sh, Rebrova D V, Krasnov L M, Fedorov E A, Chinchuk I K, Chernikov R A, Rusakov V F, Slepstov I V, Zgoda E A

机构信息

Saint Petersburg State University, Clinic of High Medical Technologies named after. N.I. Pirogova.

出版信息

Probl Endokrinol (Mosk). 2023 Nov 11;69(5):39-44. doi: 10.14341/probl13283.

Abstract

This review article contains a summary of modern aspects of preoperative preparation, surgical treatment, and follow-up of patients with adrenal pheochromocytomas. The main component of preoperative preparation is the use of alpha-blockers. The need to prescribe them to all patients is increasingly disputed, especially for patients without severe hypertension. An increasing number of publications demonstrate positive results of treatment without the use of alpha-blockers, advocating an individual approach and the use of the drug according to certain indications. Minimally invasive endoscopic techniques of adrenalectomy have become widespread in surgical treatment. They are represented by laparoscopic and retroperitonescopic technic, including using their single-port modifications. The earliest possible intersection of the central vein in the past was considered the most important aspect of adrenalectomy for pheochromocytoma, currently, due to the development of surgical techniques and anesthesiological manuals, this has ceased to be a mandatory rule of successful surgery. Despite the significant influence of the intersection of this vessel on intraoperative hemodynamics, surgical tactics with its later intersection have their own justifications and do not lead to a deterioration in treatment results. The standard volume of surgical intervention for pheochromocytomas is total adrenalectomy, however, in the presence of hereditary syndromes, such as multiple endocrine neoplasia type 2 syndrome, neurofibomatosis type 1, von Hippel-Lindau syndrome, it is possible to perform cortical-sparing adrenalectomy.

摘要

这篇综述文章总结了肾上腺嗜铬细胞瘤患者术前准备、手术治疗及随访的现代相关内容。术前准备的主要组成部分是使用α受体阻滞剂。给所有患者都开此类药物的必要性越来越受到质疑,尤其是对于无严重高血压的患者。越来越多的出版物表明,不使用α受体阻滞剂的治疗也有积极效果,主张采用个体化方法并根据特定指征使用该药物。肾上腺切除术的微创内镜技术在手术治疗中已广泛应用。它们以腹腔镜和后腹腔镜技术为代表,包括使用其单孔改良技术。过去,尽可能早地结扎中央静脉被认为是嗜铬细胞瘤肾上腺切除术最重要的方面,目前,由于手术技术和麻醉手册的发展,这已不再是成功手术的强制性规则。尽管结扎该血管对术中血流动力学有重大影响,但后期结扎的手术策略也有其合理性,且不会导致治疗效果变差。嗜铬细胞瘤手术干预的标准术式是全肾上腺切除术,然而,在存在遗传性综合征,如2型多发性内分泌腺瘤综合征、1型神经纤维瘤病、冯·希佩尔-林道综合征时,可行保留皮质的肾上腺切除术。

相似文献

1
[Surgical treatment of pheochromocytoma].[嗜铬细胞瘤的外科治疗]
Probl Endokrinol (Mosk). 2023 Nov 11;69(5):39-44. doi: 10.14341/probl13283.
4
Surgical management of hereditary pheochromocytoma.遗传性嗜铬细胞瘤的外科治疗
J Am Coll Surg. 2004 Apr;198(4):525-34; discussion 534-5. doi: 10.1016/j.jamcollsurg.2003.12.001.

本文引用的文献

7
Pheochromocytoma: A three-decade clinical experience in a multicenter study.嗜铬细胞瘤:一项多中心研究的三十年临床经验。
Rev Clin Esp (Barc). 2021 Jan;221(1):18-25. doi: 10.1016/j.rceng.2019.12.011. Epub 2020 Nov 25.
8
Pheochromocytoma and Paraganglioma: From Treatment to Follow-up.嗜铬细胞瘤和副神经节瘤:从治疗到随访
Sisli Etfal Hastan Tıp Bul. 2020 Dec 11;54(4):391-398. doi: 10.14744/SEMB.2020.58998. eCollection 2020.

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