Whitney Ashleigh J, Lindeque Zander, Kruger Ruan, Steyn Stephan F
Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa.
Acta Neuropsychiatr. 2023 Nov 16:1-15. doi: 10.1017/neu.2023.52.
We aimed to answer the questions of whether early-life (perinatal and/or juvenile) exercise can induce antidepressant-like effects in a validated rodent model of depression, and whether such early-life intervention could prevent or reverse the adverse effects of early-life stress in their offspring.
Male and female Flinders sensitive line rats born to a dam that exercised during gestation, or not, were either maternally separated between PND02 and 16 and weaned on PND17 or not. Half of these animals then underwent a fourteen-day low-intensity exercise regimen from PND22. Baseline depressive-like behaviour was assessed on PND21 and then reassessed on PND36, whereafter hippocampal monoamine levels, redox state markers and metabolic markers relevant to mitochondrial function were measured.
Pre-pubertal exercise was identified as the largest contributing factor to the observed effects, where it decreased immobility time in the FST by 6%, increased time spent in the open arms of the EPM by 9%. Hippocampal serotonin and norepinephrine levels were also increased by 35% and 26%, respectively, whilst nicotinic acid was significantly decreased.
These findings suggest that pre-pubertal low-intensity exercise induces beneficial biological alterations that could translate into antidepressant behaviour in genetically susceptible individuals.
我们旨在回答以下问题：早期生活（围产期和/或幼年）运动是否能在经过验证的抑郁症啮齿动物模型中诱导出抗抑郁样效应，以及这种早期生活干预是否能预防或逆转其后代早期生活应激的不利影响。
出生于孕期运动或未运动的母鼠的雄性和雌性弗林德斯敏感品系大鼠，在出生后第2天至16天进行或不进行母婴分离，并于出生后第17天断奶。其中一半动物在出生后第22天开始进行为期14天的低强度运动方案。在出生后第21天评估基线抑郁样行为，然后在出生后第36天重新评估，之后测量海马单胺水平、氧化还原状态标志物以及与线粒体功能相关的代谢标志物。
青春期前运动被确定为观察到的效应的最大促成因素，它使强迫游泳试验中的不动时间减少了6%，使高架十字迷宫开放臂的停留时间增加了9%。海马中的血清素和去甲肾上腺素水平也分别增加了35%和26%，而烟酸显著降低。
这些发现表明，青春期前的低强度运动可诱导有益的生物学改变，这可能转化为遗传易感个体的抗抑郁行为。
