胶束催化：一种绿色解决方案，用于在具有挑战性的β位实现（寡）噻吩的无定向温和C-H活化。

Micellar catalysis: a green solution to enable undirected and mild C-H activation of (oligo)thiophenes at the challenging β-position.

作者信息

Hauk Pascal, Mazan Valérie, Gallou Fabrice, Wencel-Delord Joanna

机构信息

Laboratoire d'Innovation Moléculaire et Applications (UMR CNRS 7042), Université de Strasbourg, Université de Haute Alsace, ECPM 67087 Strasbourg France

Chemical & Analytical Development, Novartis Pharma AG 4056 Basel Switzerland

出版信息

Chem Sci. 2023 Oct 5;14(43):12049-12055. doi: 10.1039/d3sc03708h. eCollection 2023 Nov 8.

The unexpected potential of micellar medium to achieve challenging β-selective direct arylation of (oligo)thiophenes is reported. Thanks to the use of a water/surfactant solution in combination with natural feedstock-derived undecanoic acid as an additive, this high-yielding C-H coupling could be performed regioselectively at room temperature.