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Metformin to Prevent Anthracycline Cardiotoxicity?: That Would Be Sweet!

作者信息

El-Rayes Malak, Nadler Michelle B, Abdel-Qadir Husam

机构信息

Department of Medicine, Division of Cardiology, Ted Rogers Program in Cardiotoxicity Prevention, Peter Munk Cardiac Center, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Department of Medicine, Division of Cardiology, Centre intégré de santé et de services sociaux de Laval, Hôpital Cité de la Santé, Laval, Quebec, Canada.

出版信息

JACC CardioOncol. 2023 Aug 29;5(5):683-685. doi: 10.1016/j.jaccao.2023.07.004. eCollection 2023 Oct.

DOI:10.1016/j.jaccao.2023.07.004
PMID:37969641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10635862/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bebc/10635862/1651e99825ee/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bebc/10635862/1651e99825ee/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bebc/10635862/1651e99825ee/ga1.jpg

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本文引用的文献

1
The Association of Metformin With Heart Failure in Patients With Diabetes Mellitus Receiving Anthracycline Chemotherapy.接受蒽环类化疗的糖尿病患者中二甲双胍与心力衰竭的关联
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2
Cardioprotection in Patients at High Risk of Anthracycline-Induced Cardiotoxicity: Primer.蒽环类药物诱导心脏毒性高危患者的心脏保护：入门知识
JACC CardioOncol. 2023 Jun 20;5(3):292-297. doi: 10.1016/j.jaccao.2023.05.004. eCollection 2023 Jun.
3
The Effect of Metformin on Chemotherapy-Induced Toxicities in Non-diabetic Breast Cancer Patients: A Randomised Controlled Study.
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Drug Saf. 2023 Jun;46(6):587-599. doi: 10.1007/s40264-023-01305-4. Epub 2023 May 2.
4
Doxorubicin downregulates autophagy to promote apoptosis-induced dilated cardiomyopathy via regulating the AMPK/mTOR pathway.阿霉素通过调节AMPK/mTOR信号通路下调自噬，促进凋亡诱导的扩张型心肌病。
Biomed Pharmacother. 2023 Jun;162:114691. doi: 10.1016/j.biopha.2023.114691. Epub 2023 Apr 14.
5
Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?二甲双胍作为癌症治疗药物的再利用是否仍然值得追求？
Br J Cancer. 2023 Apr;128(6):958-966. doi: 10.1038/s41416-023-02204-2. Epub 2023 Feb 23.
6
9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2023.9. 血糖治疗的药物学方法：2023 年糖尿病的护理标准。
Diabetes Care. 2023 Jan 1;46(Suppl 1):S140-S157. doi: 10.2337/dc23-S009.
7
Metformin Use Is Associated With a Lower Risk of Hospitalization for Heart Failure in Patients With Type 2 Diabetes Mellitus: a Retrospective Cohort Analysis.二甲双胍的使用与 2 型糖尿病患者心力衰竭住院风险降低相关：一项回顾性队列分析。
J Am Heart Assoc. 2019 Nov 5;8(21):e011640. doi: 10.1161/JAHA.118.011640. Epub 2019 Oct 21.
8
Interventions for preventing cardiomyopathy due to anthracyclines: a Bayesian network meta-analysis.蒽环类抗生素致心肌病的预防干预措施：贝叶斯网状荟萃分析。
Ann Oncol. 2017 Mar 1;28(3):628-633. doi: 10.1093/annonc/mdw671.
9
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J Clin Oncol. 2016 Jul 1;34(19):2239-46. doi: 10.1200/JCO.2015.65.1505. Epub 2016 Apr 18.
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Am J Cardiol. 2015 Aug 1;116(3):442-6. doi: 10.1016/j.amjcard.2015.04.064. Epub 2015 May 14.