Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
J Magn Reson Imaging. 2024 Aug;60(2):483-494. doi: 10.1002/jmri.29129. Epub 2023 Nov 16.
Three-dimensional (3D) ventilation flow capacity-weighted (VFCW) maps together with 3D ventilation-weighted (VW) maps may help to better assess pulmonary function.
To investigate the use of 3D VFCW and VW maps for evaluating pulmonary ventilation function.
Prospective.
Two patients (one male, 85 years old; one female, 64 years old) with chronic obstructive pulmonary disease (COPD) and nine healthy subjects (all male; 23-27 years).
FIELD STRENGTH/SEQUENCE: 3-T, 3D radial UTE imaging.
3D VFCW and VW maps were calculated from 3D UTE MRI by voxel-wise subtraction of respiratory phase images. Their validation was tested in nine healthy volunteers using slow/deep and fast/shallow breathing conditions. Additional validation was performed by comparison with single photon emission computed tomography (SPECT) ventilation maps of one healthy participant. For comparison, gravity dependence of anterior-posterior regional ventilation was assessed by one-dimensional plot of the mean signal intensity for each coronal slice. Structural similarity index measure was also calculated. Finally, VW maps and VFCW maps of two COPD patients were evaluated for emphysema lesions with reference to CT images.
Wilcoxon sign-rank tests for regional Ventilation and ventilation flow capacity, analysis of variance, post-hoc t-tests and Bonferroni correction, coefficient of variation, Kullback-Liebler divergence. A P-value <0.05 was considered statistically significant.
The validation of 3D VFCW and VW maps was shown by statistically significant differences in ventilation flow capacity and ventilation between the breathing conditions. Additionally, UTE-MRI and SPECT-based ventilation maps showed gravitational dependence in the anteroposterior direction. When applied to patients with COPD, the use of 3D VFCW and VW maps was able to differentiate between two patients with different phenotypes.
The use of 3D VFCW and VW maps can provide regional information on ventilation function and potentially contribute to assessment of COPD subtypes and disease progression.
2 TECHNICAL EFFICACY: Stage 1.
三维（3D）通风流量加权（VFCW）图与 3D 通风加权（VW）图相结合，有助于更好地评估肺功能。
研究 3D VFCW 和 VW 图在评估肺通气功能中的应用。
前瞻性。
两名患有慢性阻塞性肺疾病（COPD）的患者（男，85 岁；女，64 岁）和九名健康受试者（均为男性；23-27 岁）。
磁场强度/序列：3T，3D 径向 UTE 成像。
通过对呼吸相位图像进行体素减影，从 3D UTE MRI 中计算出 3D VFCW 和 VW 图。通过对九名健康志愿者进行慢/深呼吸和快/浅呼吸条件下的验证测试。通过与一名健康受试者的单光子发射计算机断层扫描（SPECT）通气图进行比较，进行了额外的验证。为了进行比较，还通过对每个冠状切片的平均信号强度进行一维绘图来评估前-后区域通气的重力依赖性。还计算了结构相似性指数度量。最后，根据 CT 图像评估了两名 COPD 患者的 VW 图和 VFCW 图在肺气肿病变方面的表现。
采用 Wilcoxon 符号秩检验进行区域通气和通气流量的比较，采用方差分析、事后 t 检验和 Bonferroni 校正、变异系数、Kullback-Leibler 散度进行分析。P 值<0.05 被认为具有统计学意义。
3D VFCW 和 VW 图的验证结果显示，在呼吸条件下，通气流量和通气能力存在统计学显著差异。此外，UTE-MRI 和基于 SPECT 的通气图显示了前-后方向的重力依赖性。当应用于 COPD 患者时，3D VFCW 和 VW 图的使用能够区分两种具有不同表型的患者。
使用 3D VFCW 和 VW 图可以提供通气功能的区域信息，并可能有助于评估 COPD 亚型和疾病进展。
2 技术功效：1 级。
