纽约州 2001-2022 年 Jamestown Canyon 病毒的监测和遗传分析。

Surveillance and Genetic Analysis of Jamestown Canyon Virus in New York State: 2001-2022.

机构信息

New York State Department of Health, The Arbovirus Laboratory, Wadsworth Center, Slingerlands, New York.

New York State Department of Health, Bureau of Communicable Disease Control, Albany, New York.

出版信息

Am J Trop Med Hyg. 2023 Oct 9;109(6):1329-1332. doi: 10.4269/ajtmh.23-0392. Print 2023 Dec 6.

DOI:10.4269/ajtmh.23-0392

PMID:37972332

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10793055/

Abstract

Jamestown Canyon virus (JCV) (Peribunyavirdae; Orthobunyavirus) is a mosquito-borne pathogen endemic to North America. The genome is composed of three segmented negative-sense RNA fragments designated as small, medium, and large. Jamestown Canyon virus is an emerging threat to public health, and infection in humans can cause severe neurological diseases, including encephalitis and meningitis. We report JCV mosquito surveillance data from 2001 to 2022 in New York state. Jamestown Canyon virus was detected in 12 mosquito species, with the greatest prevalence in Aedes canadensis and Anopheles punctipennis. Detection fluctuated annually, with the highest levels recorded in 2020. Overall, JCV infection rates were significantly greater from 2012 to 2022 compared with 2001 to 2011. Full-genome sequencing and phylogenetic analysis were also performed with representative JCV isolates collected from 2003 to 2022. These data demonstrated the circulation of numerous genetic variants, broad geographic separation, and the first identification of lineage B JCV in New York state in 2022.

摘要

詹姆士敦峡谷病毒（JCV）（Peribunyavirdae；Orthobunyavirus）是一种地方性的北美的虫媒病原体。基因组由三个分段的负义 RNA 片段组成，分别命名为小、中、大。JCV 是对公共卫生的新威胁，人类感染会导致严重的神经系统疾病，包括脑炎和脑膜炎。我们报告了 2001 年至 2022 年在纽约州的 JCV 蚊虫监测数据。在 12 种蚊虫中检测到 JCV，其中以加拿大伊蚊和致倦库蚊的流行率最高。检测结果每年波动，2020 年记录的水平最高。总体而言，与 2001 年至 2011 年相比，2012 年至 2022 年 JCV 感染率显著更高。还对 2003 年至 2022 年收集的代表性 JCV 分离株进行了全基因组测序和系统发育分析。这些数据表明存在大量遗传变异、广泛的地理分离以及 2022 年在纽约州首次鉴定出 B 谱系 JCV。