Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China; Department of Nephrology, The First Hospital of Tsinghua University, Beijing, 100016, China.
Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Eur J Pharmacol. 2023 Dec 15;961:176198. doi: 10.1016/j.ejphar.2023.176198. Epub 2023 Nov 14.
The pathogenesis of immunoglobulin A nephropathy (IgAN) is closely related to immunity and inflammation. The clinical process of IgAN varies greatly, making the assessment of prognosis challenging and limiting progress on effective treatment measures. Autophagy is an important pathway for the development of IgAN. However, the role of autophagy in IgAN is complex, and the consequences of autophagy may change during disease progression. In the present study, we evaluated the dynamic changes in autophagy during IgAN. Specifically, we examined autophagy in the kidney of a rat model of IgAN at different time points. We found that autophagy was markedly and persistently induced in IgAN rats, and the expression level of inflammation was also persistently elevated. The autophagy enhancer rapamycin and autophagy inhibitor 3-methyladenine were used in this study, and the results showed that 3-methyladenine can alleviate renal injury and inflammation in IgAN rats. Our study provides further evidence for autophagy as a therapeutic target for IgAN.
IgA 肾病（IgAN）的发病机制与免疫和炎症密切相关。IgAN 的临床过程差异很大，这使得预后评估具有挑战性，并限制了有效治疗措施的进展。自噬是 IgAN 发展的重要途径。然而，自噬在 IgAN 中的作用较为复杂，自噬的后果可能在疾病进展过程中发生变化。在本研究中，我们评估了 IgAN 过程中自噬的动态变化。具体来说，我们在不同时间点检测了 IgAN 大鼠肾脏中的自噬。我们发现 IgAN 大鼠的自噬明显且持续增强，炎症的表达水平也持续升高。本研究中使用了自噬增强剂雷帕霉素和自噬抑制剂 3-甲基腺嘌呤，结果表明 3-甲基腺嘌呤可以减轻 IgAN 大鼠的肾损伤和炎症。我们的研究为自噬作为 IgAN 的治疗靶点提供了进一步的证据。
