Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, China.
Ren Fail. 2023 Dec;45(1):2195012. doi: 10.1080/0886022X.2023.2195012.
IgA nephropathy (IgAN), an immune-mediated chronic inflammatory kidney disease, is the most common primary glomerular disease in Asia, especially in China and Japan. The pathogenesis of IgAN is complex, and the main cause of IgAN is explained by the 'multiple hit' theory, which states that the deposition of immune complexes in renal mesangial cells induces chronic inflammation that leads to kidney damage. Chronic inflammation is associated with iron metabolism, which also plays an essential role in the pathogenesis, progression, diagnosis and prognosis of IgAN. Overall, this review aimed to explore the application of iron metabolism in IgAN by systematically elaborating the relationship between iron metabolism and chronic inflammation in IgAN to speculate on the possible diagnostic and therapeutic significance of iron metabolism indicators in IgAN.
IgA 肾病（IgAN）是一种免疫介导的慢性炎症性肾脏疾病，是亚洲最常见的原发性肾小球疾病，尤其在中国和日本。IgAN 的发病机制复杂，其主要病因用“多打击”理论来解释，即免疫复合物在肾小球系膜细胞中的沉积引起慢性炎症，导致肾脏损伤。慢性炎症与铁代谢有关，铁代谢在 IgAN 的发病机制、进展、诊断和预后中也起着至关重要的作用。总的来说，本综述旨在通过系统阐述 IgAN 中铁代谢与慢性炎症的关系，探讨铁代谢在 IgAN 中的应用，推测铁代谢指标在 IgAN 中的可能诊断和治疗意义。
