Gosnell B A, Lipton J M
Peptides. 1986 Sep-Oct;7(5):745-7. doi: 10.1016/0196-9781(86)90089-6.
The food intake of rabbits was measured after intracerebroventricular injections of several opioid agonists and naloxone. The preferential kappa agonist dynorphin A increased intake, while naloxone, [D-Ser2,Leu5]enkephalin-Thr6 and Tyr-D-Ala-Gly-(Me)Phe-Gly-ol reduced intake or had no effect. These results suggest that kappa receptors have a role in the control of feeding in rabbits.
在向兔脑室内注射几种阿片类激动剂和纳洛酮后,测量了兔的食物摄入量。选择性κ激动剂强啡肽A增加了摄入量,而纳洛酮、[D-丝氨酸2,亮氨酸5]脑啡肽-苏氨酸6和酪氨酰-D-丙氨酰-甘氨酸-(甲基)苯丙氨酸-甘醇降低了摄入量或无作用。这些结果表明κ受体在兔摄食控制中起作用。