Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia; Neuroscience Research Institute, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Trends Cancer. 2024 Jan;10(1):8-11. doi: 10.1016/j.trecan.2023.10.005. Epub 2023 Nov 14.
Immunogenic cell death (ICD) arouses great interest in targeting glioma, the most common primary brain tumor, to achieve boosted immunotherapy. We discuss the unexpected findings on the induction of Th17 immunity by ICD and propose the best design for dendritic cell (DC)-based vaccines loaded with whole glioma lysates obtained after ICD inducers.
免疫原性细胞死亡 (ICD) 在靶向脑胶质瘤（最常见的原发性脑肿瘤）以实现增强免疫治疗方面引起了极大的兴趣。我们讨论了 ICD 诱导 Th17 免疫的意外发现，并提出了用 ICD 诱导剂获得的全胶质瘤裂解物负载的树突状细胞 (DC) 疫苗的最佳设计。
