Waldroup P W, Ndife L I, Hellwig H M, Hebert J A, Berrio L
Poult Sci. 1986 Oct;65(10):1949-54. doi: 10.3382/ps.0651949.
Addition of the hypocholesteremic agent Probucol ((4,4'-isopropylidine dithio)-bis(2,6-di-t-butyl-phenol)) to the diet of laying hens at up to 1% significantly reduced egg yolk cholesterol content (mg/g yolk) without impairment of rate of egg production, egg weight, shell strength, albumen quality, or other production related parameters. Dietary concentration of .1% Probucol significantly reduced yolk cholesterol within 2 weeks after feeding. Higher concentrations did not further reduce yolk cholesterol. Probucol at .025% reduced egg yolk cholesterol within 4 weeks after feeding, but after 8 weeks of feeding, eggs from hens fed .025% Probucol did not differ significantly in yolk cholesterol from those fed the basal unsupplemented diet. This suggests possible adaptation in cholesterol synthesis by the laying hen.
在产蛋母鸡的日粮中添加高达1%的降胆固醇药物普罗布考（(4,4'-亚异丙基二硫代)-双(2,6-二叔丁基苯酚)）可显著降低蛋黄胆固醇含量（毫克/克蛋黄），且不影响产蛋率、蛋重、蛋壳强度、蛋白质量或其他与生产相关的参数。日粮中添加0.1%的普罗布考在喂食后2周内可显著降低蛋黄胆固醇。更高的浓度并未进一步降低蛋黄胆固醇。添加0.025%的普罗布考在喂食后4周内可降低蛋黄胆固醇，但在喂食8周后，喂食0.025%普罗布考的母鸡所产鸡蛋的蛋黄胆固醇与喂食未添加该药物的基础日粮的母鸡所产鸡蛋相比，差异不显著。这表明产蛋母鸡在胆固醇合成方面可能存在适应性变化。
