Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.
School of Public Health, Southeast University, Nanjing, Jiangsu, 210000, China.
Nat Commun. 2023 Nov 16;14(1):7219. doi: 10.1038/s41467-023-42727-z.
Frailty is characterized by diminished resilience to stressor events. It is associated with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates ~24-h rhythms in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian disturbances with incident frailty in over 1000 older adults who had been followed annually for up to 16 years. We found that decreased rhythm strength, reduced stability, or increased variation were associated with a higher risk of incident frailty and faster progress of frailty over time. Perturbed circadian rest-activity rhythms may be an early sign or risk factor for frailty in older adults.
衰弱的特点是对压力事件的弹性降低。它与未来不良的健康结果有关,并阻碍健康老龄化。昼夜节律系统协调身体功能的约 24 小时节律与昼夜周期同步,昼夜节律调节紊乱在许多与年龄相关的健康后果中起着重要作用。我们调查了 1000 多名老年人的昼夜节律紊乱与偶发性衰弱之间的前瞻性关联,这些老年人每年接受随访,最长达 16 年。我们发现,节律强度降低、稳定性降低或变异性增加与偶发性衰弱的风险增加以及衰弱随时间的进展加快有关。紊乱的昼夜休息-活动节律可能是老年人衰弱的早期迹象或危险因素。