Loewenthal Julia V, Bart Nicole K, Burton Wren, Kamali Shaida, Montgomery Elyn, Lee Ivey Kerry, Friedman Susan M, Orkaby Ariela
Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (JVL, KLI, AO).
Cardiology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (NKB).
Am J Lifestyle Med. 2025 Aug 29:15598276251370606. doi: 10.1177/15598276251370606.
Frailty is a multidimensional syndrome associated with a state of vulnerability to external stressors. Though women have a longer life expectancy than men, they have a higher risk of frailty. Frailty is prevalent in women, affecting ∼9-15% of community-dwelling older women, and over 50% of nursing home residents. Women have unique risk factors for frailty at distinct life stages such as pregnancy and menopause. Women who have children at a young age and those who experience premature menopause have a higher risk of developing frailty later in life. Frailty is modifiable, and preventive strategies can be implemented using the framework of the six pillars of lifestyle medicine. Moreover, frailty is also a therapeutic target, with the best approach to prevention occurring earlier in life. Implementation of the six-pillar approach to frailty prevention is best achieved by considering specific benefits and barriers to each pillar for women. For example, implementing strength training alongside diet optimization while bolstering social connections. The six pillars are closely interrelated. As such, a holistic approach targeting all six has the greatest potential for success. Future studies are needed to guide therapeutic interventions specific to preventing frailty in women.
衰弱是一种与对外界应激源易感性相关的多维综合征。尽管女性的预期寿命比男性长，但她们患衰弱的风险更高。衰弱在女性中很普遍，影响约9% - 15%的社区老年女性，以及超过50%的养老院居民。女性在不同生命阶段如怀孕和绝经时有独特的衰弱风险因素。年轻时生育孩子的女性和经历过早绝经的女性在晚年患衰弱的风险更高。衰弱是可改变的，可以使用生活方式医学六大支柱的框架实施预防策略。此外，衰弱也是一个治疗靶点，最佳的预防方法是在生命早期进行。通过考虑每个支柱对女性的具体益处和障碍，最好地实现衰弱预防的六大支柱方法。例如，在优化饮食的同时进行力量训练，并加强社会联系。这六大支柱紧密相关。因此，针对所有六大支柱的整体方法取得成功的潜力最大。需要未来的研究来指导针对预防女性衰弱的特定治疗干预措施。
