Weigel R Kenton, Rangamani Adithya, Alabi Christopher A
Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.
Nat Rev Chem. 2023 Dec;7(12):875-888. doi: 10.1038/s41570-023-00556-0. Epub 2023 Nov 16.
Creating the next generation of advanced materials will require controlling molecular architecture to a degree typically achieved only in biopolymers. Sequence-defined polymers take inspiration from biology by using chain length and monomer sequence as handles for tuning structure and function. These sequence-defined polymers can assemble into discrete structures, such as molecular duplexes, via reversible interactions between functional groups. Selectivity can be attained by tuning the monomer sequence, thereby creating the need for chemical platforms that can produce sequence-defined polymers at scale. Developing sequence-defined polymers that are specific for their complementary sequence and achieve their desired binding strengths is critical for producing increasingly complex structures for new functional materials. In this Review Article, we discuss synthetic platforms that produce sequence-defined, duplex-forming oligomers of varying length, strength and association mode, and highlight several analytical techniques used to characterize their hybridization.
创造下一代先进材料需要将分子结构控制在通常只有生物聚合物才能达到的程度。序列定义聚合物从生物学中汲取灵感，通过使用链长和单体序列来调节结构和功能。这些序列定义聚合物可以通过官能团之间的可逆相互作用组装成离散结构，如分子双链体。通过调节单体序列可以实现选择性，从而产生对能够大规模生产序列定义聚合物的化学平台的需求。开发对其互补序列具有特异性并达到所需结合强度的序列定义聚合物对于生产用于新型功能材料的日益复杂的结构至关重要。在这篇综述文章中，我们讨论了能够生产不同长度、强度和缔合模式的序列定义、形成双链体的低聚物的合成平台，并重点介绍了几种用于表征其杂交的分析技术。
