Centre for Eye Research Ireland, School of Physics, Clinical & Optometric Sciences, Technological University Dublin, Dublin, Ireland.
Centre for Eye Research Ireland, School of Mathematical Sciences, Technological University Dublin, Dublin, Ireland.
J Glaucoma. 2024 Feb 1;33(2):78-86. doi: 10.1097/IJG.0000000000002331. Epub 2023 Oct 26.
Patients with glaucoma demonstrated deficiencies in their ability to process multisensory information when compared with controls, with those deficiencies being related to glaucoma severity. Impaired multisensory integration (MSI) may affect the quality of life in individuals with glaucoma and may contribute to the increased prevalence of falls and driving safety concerns. Therapeutic possibilities to influence cognition in glaucoma should be explored.
Glaucoma is a neurodegenerative disease of the optic nerve that has also been linked to cognitive health decline. This study explored MSI as a function of glaucoma status and severity.
MSI was assessed in 37 participants with open angle glaucoma relative to 18 age-matched healthy controls. The sound-induced flash illusion was used to assess MSI efficiency. Participants were presented with various combinations of simultaneous visual and/or auditory stimuli and were required to indicate the number of visual stimuli observed for each of the 96 total presentations. Central retinal sensitivity was assessed as an indicator of glaucoma severity (MAIA; CenterVue).
Participants with glaucoma performed with equivalent capacity to healthy controls on unisensory trials ( F1,53 =2.222, P =0.142). Both groups performed equivalently on congruent multisensory trials involving equal numbers of auditory and visual stimuli F1,53 =1.032, P =0.314). For incongruent presentations, that is, 2 beeps and 1 flash stimulus, individuals with glaucoma demonstrated a greater influence of the incongruent beeps when judging the number of flashes, indicating less efficient MSI relative to age-matched controls ( F1,53 =11.45, P <0.002). In addition, MSI performance was positively correlated with retinal sensitivity ( F3,49 =4.042, P <0.025), adjusted R ²=0.15).
Individuals with open angle glaucoma exhibited MSI deficiencies that relate to disease severity. The type of deficiencies observed were similar to those observed among older individuals with cognitive impairment and balance issues. Impaired MSI may, therefore, be relevant to the increased prevalence of falls observed among individuals with glaucoma, a concept that merits further investigation.
与对照组相比，青光眼患者在处理多感官信息的能力上存在缺陷，这些缺陷与青光眼的严重程度有关。多感官整合（MSI）受损可能会影响青光眼患者的生活质量，并可能导致跌倒和驾驶安全问题的发生率增加。应该探索影响青光眼认知的治疗可能性。
青光眼是一种视神经的神经退行性疾病，也与认知健康下降有关。本研究探讨了 MSI 作为青光眼状态和严重程度的函数。
37 名开角型青光眼患者和 18 名年龄匹配的健康对照者进行了 MSI 评估。使用声音诱导的闪光错觉来评估 MSI 效率。向参与者呈现各种视觉和/或听觉刺激的组合，并要求他们为 96 次总呈现中的每一次指示观察到的视觉刺激的数量。中央视网膜敏感性作为青光眼严重程度的指标（MAIA；CenterVue）进行评估。
青光眼患者在单感官试验中的表现与健康对照组相当（ F1,53 =2.222， P =0.142）。两组在涉及相等数量的听觉和视觉刺激的一致多感官试验中表现相当（ F1,53 =1.032， P =0.314）。对于不一致的呈现，即 2 个蜂鸣声和 1 个闪光刺激，青光眼患者在判断闪光刺激数量时表现出对不一致的蜂鸣声更大的影响，表明 MSI 效率相对年龄匹配的对照组较低（ F1,53 =11.45， P <0.002）。此外，MSI 表现与视网膜敏感性呈正相关（ F3,49 =4.042， P <0.025），调整后的 R ²=0.15）。
开角型青光眼患者表现出与疾病严重程度相关的 MSI 缺陷。观察到的缺陷类型与认知障碍和平衡问题老年人中观察到的缺陷类型相似。受损的 MSI 可能与青光眼患者中观察到的跌倒发生率增加有关，这一概念值得进一步研究。
