间隙连接蛋白及其在神经系统相关疾病中的潜在作用综述

A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease.

作者信息

Xiang Qiong, Liu Xiao-Lin, Chen Jia-Jia, Yang Liang, Liu Li-Ni, Deng Jing, Tao Jia-Sheng, Li Xian-Hui

机构信息

Institute of Medicine, Medical Research Center, Jishou University, Hunan, China.

Institute of Pharmaceutical Sciences, Jishou University, Hunan, China.

出版信息

Protein Pept Lett. 2023;30(11):891-899. doi: 10.2174/0109298665269246231023104904.

DOI:10.2174/0109298665269246231023104904

PMID:37974440

Abstract

Gap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases. In this paper, the possible mechanism of its action in nervous system-related diseases and treatment are reviewed.

摘要

间隙连接（GJ）是一种由连接蛋白组成的特殊细胞膜结构。连接蛋白广泛分布并表达于除分化的骨骼肌、红细胞和成熟精子细胞之外的所有组织中，其突变与许多遗传疾病的发生有关。它具有调节免疫反应、细胞增殖、迁移、凋亡和致癌作用等功能，这使其成为多种疾病的治疗靶点。本文对其在神经系统相关疾病中的可能作用机制及治疗进行综述。