Halperin-Walega E S, Greene F E
Pharmacology. 1986;33(5):286-91. doi: 10.1159/000138228.
To examine the role of multiple forms of cytochrome P-450 in the metabolism of endogenous substrates by lung, the oxidation of testosterone by rat lung microsomes in vitro was characterized and compared to liver. In lung, the majority of metabolism took place at the 16-position, with minor metabolism at the 15 alpha- and 2 beta-positions. Metabolism by lung was up to 200-fold less than liver and, unlike liver, was not sexually differentiated. Although under different regulatory control, similar forms of cytochrome P-450 may contribute to the hydroxylation of testosterone by rat lung and liver.
为研究多种形式的细胞色素P-450在肺对内源性底物代谢中的作用，对大鼠肺微粒体体外睾酮氧化进行了表征，并与肝脏进行了比较。在肺中，大部分代谢发生在16位，在15α和2β位有少量代谢。肺的代谢比肝脏低200倍，并且与肝脏不同，没有性别差异。尽管处于不同的调控控制下，但相似形式的细胞色素P-450可能参与大鼠肺和肝脏中睾酮的羟基化。
