U P Santosh, Kuruwatti Ashwini, V Srivaibhava, H Jemima
Department Of Otorhinolaryngology, J J M Medical College, Davanagere, Karnataka India.
Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):3205-3210. doi: 10.1007/s12070-023-03916-w. Epub 2023 Jun 15.
Thyroid disorders are the most common endocrine disorder affecting the general population. Diseases of the thyroid glands present with either an alteration of hormone secretion or as an enlargement of the thyroid gland. They vary from non-neoplastic to neoplastic lesions. The prevalence and pattern of these disorders depend on the factors like age, sex and geographic patterns. The aim of the study is to determine the histomorphological features of thyroid lesions in thyroidectomy specimens in patients who underwent thyroidectomy in tertiary care hospital. This is a retrospective study, conducted in tertiary care centre attached to government hospital. All thyroidectomy specimens received in the Department of Pathology, from January 2021 to January 2023 were included in the study. The patients who underwent thyroidectomy in view of thyroid swelling, over a period of 2 years, were selected. Data was collected from histopathological examinations done on the thyroidectomy specimens. Different histomorphological patterns were observed on microscopy. The thyroid lesions were classified into Neoplastic and Non-neoplastic based on histomorphological features and the data was segregated according to this and analysed. There was a total of 194 specimens, of which 175 were from female and 19 were from male patients. Maximum number of thyroid lesions were seen in the age group of 30-50 years. Among 194 patients, 52 (26.8%) were found to have neoplastic lesions, of whom, 25 (12.8%) patients had benign and 27(14%) patients had malignant lesion. 141(72.7%) patients had non neoplastic conditions. One patient had lymphoproliferative disorder (0.5%). In Neoplastic lesions, Among Benign lesions, Follicular adenoma was found be present in 25 patients. In malignant lesions, Papillary carcinoma was the most commonly found lesion (25 cases, 12.9%). 141(73%) patients had Non neoplastic conditions. Most commonly occurring Non neoplastic lesions were Nodular goiter (50 cases, 25.8%) followed by Colloid goiter (34cases, 17.5%), Multinodular goiter (33 cases, 17%), Hashimoto's thyroiditis (5 cases, 2.6%). Followed by Chronic lymphocytic thyroiditis (4 cases, 2.1%). The frequency of carcinoma is more common in females amongst the total thyroid lesions. Papillary carcinoma was the most frequent malignancy (12.9%) among the thyroidectomy specimens. Papillary carcinoma was the commonest malignant lesion with female preponderance whereas, nodular goiter and colloid goiter were the commonest non neoplastic lesions with female preponderance.
甲状腺疾病是影响普通人群的最常见内分泌疾病。甲状腺疾病表现为激素分泌改变或甲状腺肿大。它们涵盖从非肿瘤性病变到肿瘤性病变。这些疾病的患病率和模式取决于年龄、性别和地理分布等因素。本研究的目的是确定在三级护理医院接受甲状腺切除术的患者的甲状腺切除标本中甲状腺病变的组织形态学特征。这是一项在附属于政府医院的三级护理中心进行的回顾性研究。2021年1月至2023年1月病理科接收的所有甲状腺切除标本均纳入本研究。选取在2年期间因甲状腺肿大接受甲状腺切除术的患者。从对甲状腺切除标本进行的组织病理学检查中收集数据。显微镜下观察到不同的组织形态学模式。根据组织形态学特征将甲状腺病变分为肿瘤性和非肿瘤性，并据此对数据进行分类和分析。共有194个标本，其中175个来自女性患者，19个来自男性患者。甲状腺病变最多见于30 - 50岁年龄组。在194例患者中，52例（26.8%）被发现患有肿瘤性病变，其中25例（12.8%）为良性病变，27例（14%）为恶性病变。141例（72.7%）患者患有非肿瘤性疾病。1例患者患有淋巴增殖性疾病（0.5%）。在肿瘤性病变中, 在良性病变中，25例患者患有滤泡性腺瘤。在恶性病变中，乳头状癌是最常见的病变（25例，12.9%）。141例（73%）患者患有非肿瘤性疾病。最常见的非肿瘤性病变是结节性甲状腺肿（50例，25.8%），其次是胶样甲状腺肿（34例，17.5%）、多结节性甲状腺肿（33例，17%）、桥本甲状腺炎（5例，2.6%）。其次是慢性淋巴细胞性甲状腺炎（4例，2.1%）。在所有甲状腺病变中，癌的发生率在女性中更为常见。乳头状癌是甲状腺切除标本中最常见的恶性肿瘤（12.9%）。乳头状癌是最常见的恶性病变，以女性居多，而结节性甲状腺肿和胶样甲状腺肿是最常见的非肿瘤性病变，也以女性居多。
