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功能性鼻内镜鼻窦手术后炎症标志物对鼻息肉复发预测的比较

Comparison of Inflammatory Markers for Prediction of Recurrence of Nasal Polyp after Functional Endoscopy Sinus Surgery.

作者信息

Singh Shivendra Pratap, Jain Sachin, Keshari Sankalp, Kumar Pankaj, Prakash Anand, Singh Kriti

机构信息

Department of ENT and Head Neck Surgery, M.L.N. Medical College, Prayagraj, Uttar Pradesh India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):3596-3601. doi: 10.1007/s12070-023-04062-z. Epub 2023 Jul 10.

Abstract

The study was carried out to correlate the inflammatory markers (NLR, ELR, PLR) before and after endoscopic sinus surgery and their role in the prediction of recurrent nasal polyps. This was a hospital-based observational study carried out the 43 patients, aged between 18-45 years, admitted to the department of ENT with CRSwNP and underwent endoscopic sinus surgery. NLR, ELR & PLR values were compared for each patient and calculated from complete blood counts taken before and after surgery follow-up period at post-op 1st week, 3rd week, 3rd month, and 6th month. In our study, 12 out of 43 patients who underwent ESS showed recurrence. The mean value of ELR was higher in the pre-operative and post-operative 1st week in recurrent nasal polyp patients than in non-recurrent nasal polyps. (p-value < 0.05) but there were no significant changes in ELR values in subsequent follow-ups. There were no significant changes in NLR & PLR in the pre-operative and post-operative periods. Although recurrence was common in CRSwNP after endoscopic sinus surgery. Inflammatory markers could be used to predict the chances of recurrence. In our study, ELR is a better parameter than NLR and PLR in the assessment of the chance of recurrence.

摘要

本研究旨在关联内镜鼻窦手术前后的炎症标志物(中性粒细胞与淋巴细胞比值、红细胞沉降率、血小板与淋巴细胞比值)及其在预测复发性鼻息肉中的作用。这是一项基于医院的观察性研究,对43例年龄在18至45岁之间、因慢性鼻窦炎伴鼻息肉(CRSwNP)入住耳鼻喉科并接受内镜鼻窦手术的患者进行了研究。比较了每位患者的中性粒细胞与淋巴细胞比值、红细胞沉降率和血小板与淋巴细胞比值,并根据术后第1周、第3周、第3个月和第6个月手术随访期前后采集的全血细胞计数进行计算。在我们的研究中,43例接受内镜鼻窦手术的患者中有12例出现复发。复发性鼻息肉患者术前和术后第1周的红细胞沉降率平均值高于非复发性鼻息肉患者。(p值<0.05)但在随后的随访中红细胞沉降率值没有显著变化。术前和术后中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值均无显著变化。虽然内镜鼻窦手术后慢性鼻窦炎伴鼻息肉复发很常见。炎症标志物可用于预测复发几率。在我们的研究中,在评估复发几率方面,红细胞沉降率比中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值是更好的参数。

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Epidemiology and differential diagnosis of nasal polyps.鼻息肉的流行病学与鉴别诊断
Am J Rhinol Allergy. 2013 Nov-Dec;27(6):473-8. doi: 10.2500/ajra.2013.27.3981.

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