降低线粒体中氧化磷酸化合成ATP效率的调节剂：质子载体解偶联剂、循环氧化还原剂和解偶联剂。
Modulators reducing the efficiency of oxidative ATP synthesis in mitochondria: protonophore uncouplers, cyclic redox agents, and decouplers.
作者信息
Samartsev Victor N, Semenova Alena A, Belosludtsev Konstantin N, Dubinin Mikhail V
机构信息
Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El 424001 Russia.
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.
出版信息
Biophys Rev. 2023 Oct 3;15(5):851-857. doi: 10.1007/s12551-023-01160-8. eCollection 2023 Oct.
Abstract
This work considers the main indicators of the oxidative phosphorylation efficiency in mitochondria: the ADP/O and H/O ratios. Three groups of modulators that reduce the efficiency of oxidative phosphorylation are compared: protonophore uncouplers, cyclic redox compounds, and decouplers. It is noted that some of them are considered effective therapeutic agents. The paper analyzes the authors' original data on the mechanism of action of natural decouplers, represented by long-chain α,ω-dioic acids, as antioxidants. In conclusion, we discuss the hypothesis of their participation in the rescue of hepatocytes in various disorders of carbohydrate and lipid metabolism.
摘要
这项工作考虑了线粒体中氧化磷酸化效率的主要指标
ADP/O和H/O比率。比较了三组降低氧化磷酸化效率的调节剂：质子载体解偶联剂、环状氧化还原化合物和解偶联剂。值得注意的是，其中一些被认为是有效的治疗药物。本文分析了以长链α,ω-二元酸为代表的天然解偶联剂作为抗氧化剂的作用机制的作者原始数据。总之，我们讨论了它们参与在各种碳水化合物和脂质代谢紊乱中拯救肝细胞的假说。
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