Bloedow D C, Goodfellow L A, Marvin J, Heimbach D
Res Commun Chem Pathol Pharmacol. 1986 Oct;54(1):87-99.
Limited information is available describing the pharmacokinetics of hepatically-cleared drugs in burn patients. Based on the hypothesis that after burn injury, plasma meperidine clearance should increase in response to the postburn increase in hepatic blood flow, we examined the kinetics of intravenous meperidine in eleven patients about one week after burn injury (acute study) and in five of these patients about six weeks postburn (convalescent study). The meperidine steady-state distribution volume (about 2 1/kg) during both the acute and the convalescent studies was about half the distribution volume reported in the literature for meperidine in healthy subjects. The meperidine clearance in burn patients (acute, 420 ml/min and convalescent, 600 ml/min) was lower than would be anticipated in the presence of known marked increases in hepatic blood flow in burn patients.
关于烧伤患者中经肝脏清除的药物的药代动力学，目前可用信息有限。基于烧伤后肝血流量增加会导致血浆哌替啶清除率升高这一假设，我们研究了11名烧伤患者伤后约一周（急性期研究）以及其中5名患者伤后约六周（恢复期研究）静脉注射哌替啶的动力学。在急性期和恢复期研究中，哌替啶的稳态分布容积（约2升/千克）约为文献报道的健康受试者中哌替啶分布容积的一半。烧伤患者的哌替啶清除率（急性期为420毫升/分钟，恢复期为600毫升/分钟）低于预期，而烧伤患者的肝血流量已知有显著增加。
