Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, India.
Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, India.
Expert Opin Drug Deliv. 2023 Jul-Dec;20(11):1553-1571. doi: 10.1080/17425247.2023.2286368. Epub 2023 Dec 20.
With the increase in the elderly population and the prevalence of multiple medical conditions, medication adherence, and efficacy have become crucial for the effective management of their health. The aging population faces unique challenges that need to be addressed through advancements in drug delivery systems and formulation technologies.
The current review highlights the recent advances in dosage form design for older individuals, with consideration of their specific physiological and cognitive changes. Various dosage forms, such as modified-release tablets/capsules, chewable tablets, and transdermal patches, can be tailored to meet the specific needs of elderly patients. Advancements in drug delivery systems, such as nanotherapeutics, additive manufacturing (three-dimensional printing), and drug-food combinations, improve drug delivery and efficacy and overcome challenges, such as dysphagia and medication adherence.
Regulatory guidelines and considerations are crucial in ensuring the safe utilization of medications among older adults. Important factors to consider include geriatric-specific guidelines, safety considerations, labeling requirements, clinical trial considerations, and adherence and accessibility considerations.
随着老年人口的增加和多种医疗条件的流行，药物依从性和疗效对于有效管理他们的健康变得至关重要。老年人口面临着需要通过药物输送系统和配方技术的进步来解决的独特挑战。
目前的综述强调了针对老年人的剂型设计的最新进展，同时考虑了他们特定的生理和认知变化。各种剂型，如控释片剂/胶囊、咀嚼片和透皮贴剂，可以根据老年患者的具体需求进行定制。药物输送系统的进步，如纳米疗法、添加剂制造（三维打印）和药物-食品组合，改善了药物输送和疗效，并克服了吞咽困难和药物依从性等挑战。
监管指南和考虑因素对于确保老年人安全使用药物至关重要。需要考虑的重要因素包括老年特定指南、安全性考虑、标签要求、临床试验考虑以及依从性和可及性考虑。
